Amiodarone, an iodinated benzofuran derivative, was introduced in the 1960s as an
antianginal agent with coronary vasodilator properties. Later description of its antiaiThythmic …

Amiodarone was synthesized in 1961 by Tondeur and Binon in the Labaz Laboratories in
Belgium. It is a benzofuran derivative related to the obsolete vasodilator khellin …

Amiodarone has been reported as an anti-anginal drug in 19h7 [11 and as an anti-
arrhythmic drug in 1969 [2]. Thyroid side-effects (hypothyroidism and thyrotoxicosis) were …

Thyroid function alterations induced by amiodarone treatment (200-400 mg/day for 5
days/week) were studied in 50 patients with heart disease (age 34-75 years, mean age …

Amiodarone, an iodinated benzofuran derivative, has electrophysiologic effects on cardiac
muscle akin to those of hypothyroidism. It is possible that the drug exerts its salutary effect, at …

The author presents his experience with the thyroid complications of amiodarone therapy:
exceptional but sometimes serious conditions. Both, hypo-and hyperthyroidism can occur …

2-n-Butyl-3-(4'-diethylaminoethoxy-3', 5'-diiodobenzoyl)-benzofurane (amiodarone), a drug
used in arrythmias and angina pectoris, contains 75 mg of organic iodine/200 mg active …

Pituitary-thyroid function was tested in 15 euthyroid patients before, during, and after long
term oral treatment with amiodarone (2-n-butyl-3, 4′-diethylaminoethoxy-3′, 5 …

Amiodarone, an antiarrhythmic and anti-anginal agent, contains 75mg oforganic iodine per
200mg active substance. The drug is deiodinated during its biotransformation, and it is …

Serum thyroxine (T4), triiodothyronine (T3), resin uptake of T3 (RT3U), thyroid stimulating
hormone (TSH) and TSH response to thyrotropin releasing hormone (TRH) were measured …