Expression and functional properties of TRPM2 channels in dopaminergic neurons of the substantia nigra of the rat

KKH Chung, PS Freestone… - Journal of …, 2011 - journals.physiology.org
Transient receptor potential melastatin 2 (TRPM2) channels are sensitive to oxidative stress,
and their activation can lead to cell death. Although these channels have been extensively …

TRPM2: a candidate therapeutic target for treating neurological diseases

JC Belrose, MF Jackson - Acta Pharmacologica Sinica, 2018 - nature.com
Transient receptor potential melastatin 2 (TRPM2) is a calcium (Ca 2+)-permeable non-
selective cation channel belonging to the TRP ion channel family. Oxidative stress-induced …

Ca2+‐dependent induction of TRPM2 currents in hippocampal neurons

ME Olah, MF Jackson, H Li, Y Perez… - The Journal of …, 2009 - Wiley Online Library
TRPM2 is a Ca2+‐permeable member of the transient receptor potential melastatin family of
cation channels whose activation by reactive oxygen/nitrogen species (ROS/RNS) and ADP …

Activation of steroid‐sensitive TRPM3 channels potentiates glutamatergic transmission at cerebellar Purkinje neurons from developing rats

PA Zamudio‐Bulcock, J Everett… - Journal of …, 2011 - Wiley Online Library
J. Neurochem.(2011) 119, 474–485. Abstract The functional implications of transient
receptor potential melastatin 3 (TRPM3) activation, the most recently described member of …

[HTML][HTML] TRPM2 cation channels, oxidative stress and neurological diseases: where are we now?

M Nazıroğlu - Neurochemical research, 2011 - Springer
Abstract The Na+ and Ca 2+-permeable melastatin related transient receptor potential 2
(TRPM2) channels can be gated either by ADP-ribose (ADPR) in concert with Ca 2+ or by …

Characterization and optimization of the novel transient receptor potential melastatin 2 antagonist tatM2NX

I Cruz-Torres, DS Backos, PS Herson - Molecular pharmacology, 2020 - ASPET
Transient receptor potential melastatin 2 (TRPM2) is a calcium-permeable channel activated
by adenosine diphosphate ribose metabolites and oxidative stress. TRPM2 contributes to …

TRPM2 in the brain: role in health and disease

G Sita, P Hrelia, A Graziosi, G Ravegnini, F Morroni - Cells, 2018 - mdpi.com
Transient receptor potential (TRP) proteins have been implicated in several cell functions as
non-selective cation channels, with about 30 different mammalian TRP channels having …

Critical intracellular Ca2+ dependence of transient receptor potential melastatin 2 (TRPM2) cation channel activation

D McHugh, R Flemming, SZ Xu, AL Perraud… - Journal of Biological …, 2003 - ASBMB
TRPM2 is a member of the melastatin-related TRP (transient receptor potential) subfamily. It
is expressed in brain and lymphocytes and forms a cation channel that is activated by …

NGF-induced reduction of an outward-rectifying TRPM7-like current in rat CA1 hippocampal neurons

SL Tian, H Jiang, Y Zeng, LL Li, J Shi - Neuroscience letters, 2007 - Elsevier
Transient receptor potential melastatin 7 (TRPM7) channels are widely expressed in the
nervous system; however, their function and regulation are largely unknown. This study …

Oxidative stress-modulated TRPM ion channels in cell dysfunction and pathological conditions in humans

F Simon, D Varela, C Cabello-Verrugio - Cellular signalling, 2013 - Elsevier
The transient receptor potential melastatin (TRPM) protein family is an extensive group of
ion channels expressed in several types of mammalian cells. Many studies have shown that …