The placenta is a programming agent for cardiovascular disease
KL Thornburg, PF O'tierney, S Louey - Placenta, 2010 - Elsevier
Cardiovascular disease remains the number one killer in western nations in spite of declines
in death rates following improvements in clinical care. It has been 20 years since David …
in death rates following improvements in clinical care. It has been 20 years since David …
Placental weight relative to birth weight and long-term cardiovascular mortality: findings from a cohort of 31,307 men and women
KR Risnes, PR Romundstad, TIL Nilsen… - American journal of …, 2009 - academic.oup.com
Birth weight is inversely associated with risk of adult cardiovascular disease, and evidence
exists that fetal adaptation to challenges in the intrauterine environment may adversely affect …
exists that fetal adaptation to challenges in the intrauterine environment may adversely affect …
Biological features of placental programming
KL Thornburg, K Kolahi, M Pierce, A Valent, R Drake… - Placenta, 2016 - Elsevier
The placenta is a key organ in programming the fetus for later disease. This review outlines
nine of many structural and physiological features of the placenta which are associated with …
nine of many structural and physiological features of the placenta which are associated with …
Near to one's heart: the intimate relationship between the placenta and fetal heart
EJ Camm, KJ Botting, AN Sferruzzi-Perri - Frontiers in physiology, 2018 - frontiersin.org
The development of the fetal heart is exquisitely controlled by a multitude of factors, ranging
from humoral to mechanical forces. The gatekeeper regulating many of these factors is the …
from humoral to mechanical forces. The gatekeeper regulating many of these factors is the …
The placenta is the center of the chronic disease universe
KL Thornburg, N Marshall - American Journal of Obstetrics & Gynecology, 2015 - ajog.org
Over the past quarter century, the scientific community has gained a new perspective on the
origins of chronic disease, which now includes a central role for the placenta. It began when …
origins of chronic disease, which now includes a central role for the placenta. It began when …
Development of the human placenta and fetal heart: synergic or independent?
GJ Burton, E Jauniaux - Frontiers in physiology, 2018 - frontiersin.org
The placenta is the largest fetal organ, and toward the end of pregnancy the umbilical
circulation receives at least 40% of the biventricular cardiac output. It is not surprising …
circulation receives at least 40% of the biventricular cardiac output. It is not surprising …
Maternal influences on placental development
J Aplin - Seminars in Cell & Developmental Biology, 2000 - Elsevier
Epidemiological evidence suggests that size at birth may affect health in later life. The
growth of the fetus may be adversely affected by a suboptimal maternal environment …
growth of the fetus may be adversely affected by a suboptimal maternal environment …
The role of the placenta in fetal programming—a review
KM Godfrey - Placenta, 2002 - Elsevier
The fetal origins hypothesis proposes that adult cardiovascular and metabolic disease
originate through developmental plasticity and fetal adaptations arising from failure of the …
originate through developmental plasticity and fetal adaptations arising from failure of the …
The role of abnormal placentation in congenital heart disease; cause, correlate, or consequence?
JA Courtney, JF Cnota, HN Jones - Frontiers in Physiology, 2018 - frontiersin.org
Congenital heart disease (CHD) is the most common birth defect, affecting~ 1% of all live
births (van der Linde et al.,). Despite improvements in clinical care, it is the leading cause of …
births (van der Linde et al.,). Despite improvements in clinical care, it is the leading cause of …
recent advances in placenta–heart interactions
CL Maslen - Frontiers in Physiology, 2018 - frontiersin.org
Congenital heart defects (CHD) occur in∼ 1 in every 100 live births. In addition, an
estimated 10% of fetal loss is due to severe forms of CHD. This makes heart defects the most …
estimated 10% of fetal loss is due to severe forms of CHD. This makes heart defects the most …