The dynorphin/kappa opioid receptor (KOR) system is implicated in the “dark side” of
addiction, in which stress exacerbates maladaptive responses to drug and alcohol …

Evidence has demonstrated that dynorphin (DYN) and the kappa opioid receptor (KOR)
system contribute to various psychiatric disorders, including anxiety, depression, and …

Behavioral, biological, and social sequelae that lead to drug addiction differ between men
and women. Our efforts to understand addiction on a mechanistic level must include studies …

This review represents the focus of a symposium that was presented at the “Alcoholism and
Stress: A Framework for Future Treatment Strategies” conference in Volterra, Italy on May 3 …

Drug addiction is a chronic relapsing disease in which drug administration becomes the
primary stimulus that drives behavior regardless of the adverse consequence that may …

Stress is a complex experience that carries both aversive and motivating properties. Chronic
stress causes an increase in the risk of depression, is well known to increase relapse of drug …

The dynorphin/kappa opioid receptor (KOR) system has been implicated in many aspects
that influence neuropsychiatric disorders. Namely, this system modulates neural circuits that …

Over twenty years ago, kappa-opioid receptor (KOPr) agonists were reported to produce
dysphoric and psychotomimetic effects(Pfeiffer et al, 1986). In contrast to μ-opiate receptor …

Substance use disorders represent a global public health issue. This mental health disorder
is hypothesized to result from neurobiological changes as a result of chronic drug exposure …

Alcoholism is a chronic relapsing disorder characterized by continued alcohol use despite
numerous adverse consequences. Alcohol has been shown to interact with numerous …