G‐Quadruplex DNA Structures and Organic Chemistry: More Than One Connection
M Franceschin - European Journal of Organic Chemistry, 2009 - Wiley Online Library
G‐Quadruplexes represent a group of unusual DNA secondary structures, based on
Hoogsteen G–G paired hydrophobic planar rings consisting of four guanine units. Many …
Hoogsteen G–G paired hydrophobic planar rings consisting of four guanine units. Many …
Stabilizing parallel G-quadruplex DNA by a new class of ligands: two non-planar alkaloids through interaction in lateral grooves
Q Li, J Xiang, X Li, L Chen, X Xu, Y Tang, Q Zhou, L Li… - Biochimie, 2009 - Elsevier
Human DNA sequences consisting of tandem guanine (G) nucleotides can fold into a four-
stranded structure named G-quadruplex via Hoogsteen hydrogen bonding. As the …
stranded structure named G-quadruplex via Hoogsteen hydrogen bonding. As the …
A hitchhiker's guide to G-quadruplex ligands
D Monchaud, MP Teulade-Fichou - Organic & biomolecular chemistry, 2008 - pubs.rsc.org
Over the past decade, nucleic acid chemists have seen the spectacular emergence of
molecules designed to interact efficiently and selectively with a peculiar DNA structure …
molecules designed to interact efficiently and selectively with a peculiar DNA structure …
G‐quadruplex structures and their interaction diversity with ligands
S Zhang, Y Wu, W Zhang - ChemMedChem, 2014 - Wiley Online Library
G‐Quadruplexes are distinct nucleic acid secondary structures that are formed from G‐rich
DNA and RNA sequences; they are built around successive G‐tetrads of Hoogsteen …
DNA and RNA sequences; they are built around successive G‐tetrads of Hoogsteen …
Four-stranded nucleic acids: structure, function and targeting of G-quadruplexes
JL Huppert - Chemical Society Reviews, 2008 - pubs.rsc.org
There are many structures that can be adopted by nucleic acids other than the famous
Watson–Crick duplex form. This tutorial review describes the guanine rich G-quadruplex …
Watson–Crick duplex form. This tutorial review describes the guanine rich G-quadruplex …
G‐quadruplexes: targets in anticancer drug design
T Ou, Y Lu, J Tan, Z Huang… - ChemMedChem …, 2008 - Wiley Online Library
G‐quadruplexes are special secondary structures adopted in some guanine‐rich DNA
sequences. As guanine‐rich sequences are present in important regions of the eukaryotic …
sequences. As guanine‐rich sequences are present in important regions of the eukaryotic …
G-quadruplexes as targets for drug design
LH Hurley, RT Wheelhouse, D Sun, SM Kerwin… - Pharmacology & …, 2000 - Elsevier
G-quadruplexes are a family of secondary DNA structures formed in the presence of
monovalent cations that consist of four-stranded structures in which Hoogsteen base-pairing …
monovalent cations that consist of four-stranded structures in which Hoogsteen base-pairing …
Structural insights into G-quadruplexes: towards new anticancer drugs
D Yang, K Okamoto - Future medicinal chemistry, 2010 - Taylor & Francis
DNA G-quadruplexes are DNA secondary structures formed in specific G-rich sequences.
DNA sequences that can form G-quadruplexes have been found in regions with biological …
DNA sequences that can form G-quadruplexes have been found in regions with biological …
Using Macrocyclic G‐Quadruplex Ligands to Decipher the Interactions Between Small Molecules and G‐Quadruplex DNA
M Andréasson, N Bhuma… - … –A European Journal, 2022 - Wiley Online Library
This study aims to deepen the knowledge of the current state of rational G4‐ligand design
through the design and synthesis of a novel set of compounds based on indoles, quinolines …
through the design and synthesis of a novel set of compounds based on indoles, quinolines …
Looking for efficient G‐quadruplex ligands: evidence for selective stabilizing properties and telomere damage by drug‐like molecules
B Pagano, J Amato, N Iaccarino, C Cingolani… - …, 2015 - Wiley Online Library
There is currently significant interest in the development of G‐quadruplex‐interactive
compounds, given the relationship between the ability to stabilize these non‐canonical DNA …
compounds, given the relationship between the ability to stabilize these non‐canonical DNA …