Gold nanoparticle interactions with endothelial cells cultured under physiological conditions

C Freese, L Anspach, RC Deller, SJ Richards… - Biomaterials …, 2017 - pubs.rsc.org
PEGylated gold nanoparticles (AuNPs) have an extended circulation time after intravenous
injection in vivo and exhibit favorable properties for biosensing, diagnostic imaging, and …

[HTML][HTML] Synthesis of functionalized 10-nm polymer-coated gold particles for endothelium targeting and drug delivery

MJ Cheng, P Prabakaran, R Kumar… - Journal of …, 2018 - pmc.ncbi.nlm.nih.gov
Gold nanoparticles (AuNPs) have been used extensively in medical research due to their
size, biocompatibility, and modifiable surface. Specific targeting and drug delivery are some …

Polyvinylpyrrolidone-coated gold nanoparticles inhibit endothelial cell viability, proliferation, and ERK1/2 phosphorylation and reduce the magnitude of endothelial …

T Mohamed, S Matou-Nasri, A Farooq… - International journal …, 2017 - Taylor & Francis
Background Gold nanoparticles (AuNPs) demonstrate clinical potential for drug delivery and
imaging diagnostics. As AuNPs aggregate in physiological fluids, polymer-surface …

Evaluation of gold nanoparticles biocompatibility: a multiparametric study on cultured endothelial cells and macrophages

A Orlando, M Colombo, D Prosperi, F Corsi… - Journal of Nanoparticle …, 2016 - Springer
Colloidal gold nanoparticles (AuNPs) have been considered an established advanced tool
in biomedicine thanks to their physicochemical properties combined with nanoscale size …

Size-and coating-dependent uptake of polymer-coated gold nanoparticles in primary human dermal microvascular endothelial cells

C Freese, MI Gibson, HA Klok, RE Unger… - …, 2012 - ACS Publications
A library-orientated approach is used to gain understanding of the interactions of well-
defined nanoparticles with primary human endothelial cells, which are a key component of …

Uptake of poly (2-hydroxypropylmethacrylamide)-coated gold nanoparticles in microvascular endothelial cells and transport across the blood–brain barrier

C Freese, RE Unger, RC Deller, MI Gibson… - Biomaterials …, 2013 - pubs.rsc.org
The facile and modular functionalization of gold nanoparticles makes them versatile tools in
nanomedicine, for instance, photothermal therapy, contrast agents or as model …

Uptake of gold nanoparticles in primary human endothelial cells

H Klingberg, LB Oddershede, K Loeschner… - Toxicology …, 2015 - academic.oup.com
Gold nanoparticles (AuNPs) are relevant in nanomedicine for drug delivery in the vascular
system, where endothelial cells are the first point of contact. We investigated the uptake of …

Evaluation of gold nanoparticles toxicity towards human endothelial cells under static and flow conditions

C Fede, I Fortunati, V Weber, N Rossetto, F Bertasi… - Microvascular …, 2015 - Elsevier
A new in vitro model system, adding advection and shear stress associated with a flowing
medium, is proposed for the investigation of nanoparticles uptake and toxicity towards …

Transport of gold nanoparticles by vascular endothelium from different human tissues

R Gromnicova, M Kaya, IA Romero, P Williams… - PLoS …, 2016 - journals.plos.org
The selective entry of nanoparticles into target tissues is the key factor which determines
their tissue distribution. Entry is primarily controlled by microvascular endothelial cells, which …

Nanoparticle size-specific actin rearrangement and barrier dysfunction of endothelial cells

Y Liu, N Rogel, K Harada, L Jarett, CH Maiorana… - …, 2017 - Taylor & Francis
In this work, we evaluated the impact of gold nanoparticles on endothelial cell behavior and
function beyond the influence on cell viability. Five types of gold nanoparticles were studied …