Providing a broad overview of basic and clinical aspects of alpha 1-antitrypsin (a 1AT)
deficiency, this up-to-date reference discusses the complex pathobiological processes …

ABSTRACT α1-antitrypsin (α1AT) deficiency is a common lethal hereditary disorder of white
persons of European descent. The condition is characterized by reduced serum levels of α …

More than 50 years ago, the observation that absence of the α 1 band from protein
electrophoresis is associated with severe emphysema established the link between α 1 …

The classical form of α1-antitrypsin deficiency (ATD) is an autosomal co-dominant disorder
that affects~ 1 in 3000 live births and is an important genetic cause of lung and liver disease …

Alpha-1-antitrypsin (A1AT) deficiency is an autosomal hereditary disorder associated with a
major reduction in serum A1AT levels. Clinically, A1AT deficiency is associated with …

Summary Alpha‐1 antitrypsin (A1AT) is a serine anti‐protease produced chiefly by the liver.
A1AT deficiency is a genetic disorder characterized by serum levels of less than 11 μmol/L …

Abstract α1-Antitrypsin (AAT) deficiency is associated with predisposition to developing liver
cirrhosis in early childhood, and chronic degenerative lung disease in early adult life. The …

Abstract Alpha‐1 antitrypsin (AAT) deficiency is an under‐recognized hereditary disorder
associated with the premature onset of chronic obstructive pulmonary disease, liver cirrhosis …

Intravenous infusion of alpha-1 antitrypsin (AAT) was approved by the United States Food
and Drug Administration (FDA) to treat emphysema associated with AAT deficiency (AATD) …

Alpha-1 antitrypsin (A1AT) is a 52-kDa, acute phase glycoprotein encoded by the protease
inhibitor (PI) locus, located on the long arm of chromosome 14 (14q31-32.3). Its structure is …