Lipoprotein (a)[Lp (a)] concentrations are among the strongest genetic risk factors for
cardiovascular disease and present pronounced interethnic and interindividual differences …

Background The concentrations of the highly atherogenic lipoprotein (a)[Lp (a)] are mainly
genetically determined by the LPA gene locus. However, up to 70% of the coding sequence …

Background—Functional copy number variation in the apolipoprotein (a) gene (LPA)
underlies a variable number of protein kringle domains repeated in tandem in the lipoprotein …

Abstract High lipoprotein (a)[Lp (a)] concentrations are one of the most important genetically
determined risk factors for cardiovascular disease. Lp (a) concentrations are an enigmatic …

Abstract Background Lipoprotein (a)(Lp (a)) concentrations are a major independent risk
factor for coronary artery disease (CAD) and are mainly determined by variation in LPA. Up …

Abstract Lipoprotein (a)[Lp (a)] concentrations are regulated by the LPA gene mainly via the
large kringle IV-type 2 (KIV-2) copy number variation and multiple causal variants. Early …

Abstract Lipoprotein (a), Lp (a), is a modified low-density lipoprotein particle that contains
apolipoprotein (a), encoded by LPA, and is a highly heritable, causal risk factor for …

Abstract Lipoprotein (a)[Lp (a)] is an independent risk factor for atherosclerosis-related
events that is under strong genetic control (heritability= 0.68–0.98). However, causal …

The serum concentration of lipoprotein Lp (a) is known to be highly heritable and associated
with cardiovascular risk. A genome-wide variance component linkage analysis was …

BACKGROUND: Both genome-wide association studies and candidate gene studies have
reported that the major determinant of plasma levels of the Lipoprotein (a)[Lp (a)] reside …