Antimicrobial peptides (AMPs): potential therapeutic strategy against trypanosomiases?

M Rojas-Pirela, U Kemmerling, W Quiñones… - Biomolecules, 2023 - mdpi.com
Trypanosomiases are a group of tropical diseases that have devastating health and socio-
economic effects worldwide. In humans, these diseases are caused by the pathogenic …

The potential use of natural and structural analogues of antimicrobial peptides in the fight against neglected tropical diseases

A Lewies, JF Wentzel, G Jacobs, LH Du Plessis - Molecules, 2015 - mdpi.com
Recently, research into the development of new antimicrobial agents has been driven by the
increase in resistance to traditional antibiotics and Emerging Infectious Diseases …

Therapeutic potential of antimicrobial peptides against pathogenic protozoa

CL Hagemann, AJ Macedo, T Tasca - Parasitology Research, 2024 - Springer
Protozoal infections cause significant morbidity and mortality in humans and animals. The
use of several antiprotozoal drugs is associated with serious adverse effects and resistance …

Antimicrobial peptide action on parasites

M Torrent, D Pulido, L Rivas, D Andreu - Current drug targets, 2012 - ingentaconnect.com
Diseases caused by protozoan parasites can pose a severe thread to human health and are
behind some serious neglected tropical diseases like malaria and leishmaniasis. Though …

Antimicrobial peptide killing of African trypanosomes

JM Harrington - Parasite Immunology, 2011 - Wiley Online Library
The diseases caused by trypanosomes are medically and economically devastating to the
population of Sub‐Saharan Africa. Parasites of the genus Trypanosoma infect both humans …

Antimicrobial peptides: On future antiprotozoal and anthelminthic applications

K Nogrado, P Adisakwattana, O Reamtong - Acta Tropica, 2022 - Elsevier
Control and elimination of parasitic diseases are nowadays further complicated by
emergence of drug resistance. Drug resistance is a serious threat as there are not many …

Activity of Anti-Microbial Peptides (AMPs) against Leishmania and Other Parasites: An Overview

R El-Dirany, H Shahrour, Z Dirany, F Abdel-Sater… - Biomolecules, 2021 - mdpi.com
Anti-microbial peptides (AMPs), small biologically active molecules, produced by different
organisms through their innate immune system, have become a considerable subject of …

Antibacterial activity of rationally designed antimicrobial peptides

MB Tincho, T Morris, M Meyer… - International Journal of …, 2020 - Wiley Online Library
Many infectious diseases are still prevalent in the world's populations since no effective
treatments are available to eradicate them. The reasons may either be the antibiotic …

Systematic review of antiprotozoal potential of antimicrobial peptides

FA Santos, GS Cruz, FA Vieira, BRS Queiroz… - Acta Tropica, 2022 - Elsevier
Protozoa is a group of microorganisms that cause neglected tropical diseases, such as
malaria, Chagas disease, and Leishmaniasis. Due to the growing demand for new …

Antimicrobial peptides with antiprotozoal activity: current state and future perspectives

L Giovati, T Ciociola, W Magliani… - Future Medicinal …, 2018 - Taylor & Francis
Protozoal infections are responsible for significant morbidity and mortality in humans. To
date, no safe and effective vaccine is available against any human protozoal disease …