Background Currently, there is a lack of effective therapy for chronic pain. Increasing
evidence has shown that chemokines and their correlative receptors involved in the neuron …

Inflammatory cytokines and chemokines play essential roles in the occurrence and
persistence of neuropathic pain (NP). Chronic constriction injury (CCI) enhances the …

Background Neuroinflammation is identified to be crucial in the development of neuropathic
pain, whereas definite molecular mechanisms remain obscure. Recently, chemokine CXCL5 …

Emerging evidence indicates that CXCL12/CXCR4 signaling is involved in chronic pain.
However, few studies have systemically assessed its role in direct nerve injury-induced …

The anterior cingulate cortex (ACC) is activated by noxious stimuli and is involved in the
affective component of pain processing; but its role in the sensory component of pain …

Chemokines and their receptors have been demonstrated to be important contributors to the
development and maintenance of chronic pain. Recent studies showed that chemokine …

Background Previous studies have demonstrated that the CXCL12/CXCR4 signaling axis is
involved in the regulation of neuropathic pain (NP). Here, we performed experiments to test …

Chemokines and receptors have been implicated in the pathogenesis of chronic pain. Here,
we report that spinal nerve ligation (SNL) increased CXCR3 expression in dorsal root …

Peripheral nerve injury (PNI)-induced neuropathic pain is a prevalent and severe clinical
problem. It has been shown that microglia-mediated neuroinflammation plays a crucial role …

Recent studies have indicated an important role of chemokines such as CCL2 in the
development of chronic pain. However, the distinct roles of different chemokines in the …