Over the last decade, epidemiologic evidence has accumulated in favor of a significant but
heterogeneous hereditary component in prostate cancer (PC) susceptibility. In order to map …

This presentation reviews data on the familial component of prostate cancer and evidence to
support a role of genetic susceptibility in this common and complex disease. Data from case …

African American men have the highest incidence of prostate cancer in the world. Despite
this statistic, linkage studies designed to localise prostate cancer susceptibility alleles have …

Background: Familial prostate cancer has been studied in Europe and the United States.
This study was conducted toclarify the clinical features and incidenceof the human leukocyte …

Objectives. To confirm, in a study of a large, independent cohort of families with prostate
cancer, the findings of three segregation analyses that have suggested the existence of an …

BACKGROUND Familial risks by proband status and age are useful for clinical counseling,
and they can be used to calculate population‐attributable fractions (PAFs), which show the …

A 10-cM genomewide scan of 94 families with hereditary prostate cancer, including 432
affected men, was used to identify regions of putative prostate cancer–susceptibility loci …

Context.—Approximately 9% of prostate cancer cases have been estimated to result from
inheritance of mutated prostate cancer susceptibility genes. Few data exist as to whether …

A family history of prostate cancer is a consistent risk factor for prostate cancer, and can also
be used to predict the presence of prostate cancer among asymptomatic men who undergo …

Since the first report of a genome-wide scan for hereditary prostate cancer (HPCA
hereinafter) in 1996, several publications have presented data implicating various …