Abstract Objectives The Swedish Family-Cancer Database has been the major source of
population-based prospective data on familial risks on most cancers, including prostate …

Background: It is estimated that there will be more than 244 000 new prostate cancer cases
diagnosed and that more than 40 000 men will die of this disease during 1995. Evidence …

BACKGROUND Prostate cancer is a heterogeneous disease, both genetically and
phenotypically. Linkage studies attempting to map genes for hereditary prostate cancer …

Previous studies have demonstrated familial clustering of prostate cancer. To define the
nature of this familial aggregation and to assess whether Mendelian inheritance can explain …

Objectives. Prostate cancer (PCa) has a familial predisposition imparting an increased risk
of developing the disease in those with a family history. The pathologic characteristics are …

Family history of prostate cancer is one of the three most important risk factors for the
disease in addition to age and race. Yet despite the recognition of this significant heritable …

Purpose We describe the pathogenic variant spectrum and identify predictors of positive
results among men referred for clinical genetic testing for prostate cancer. Methods One …

Background Family history is a strong risk factor for prostate cancer. The aim of this study
was to investigate whether increased diagnostic activity is related to the incidence of …

BACKGROUND In this study, we evaluate the pattern of allelic imbalance (AI) in both
sporadic prostate cancer (SPC) and hereditary prostate cancer (HPC) at loci that frequently …

Prostate cancer (PrCa) ranks among the top five cancers for both incidence and mortality
worldwide. A significant proportion of PrCa susceptibility has been attributed to inherited …