Background. Family history of prostate cancer is a risk factor for prostate cancer occurrence.
Differently from other neoplasms no major predisposing gene has been identified. Material …

BACKGROUND In order to identify predisposition loci to hereditary prostate cancer (HPC),
we performed a genome‐wide linkage analysis using samples from a genetically …

Although prostate cancer (PC) has a significant mortality, there is debate regarding the utility
of PC screening. This debate continues as major studies investigating the value of …

Prostate cancer (PCa) has a large familial component, but understanding of its genetic basis
is fragmentary. Breast cancers may be associated with PCa, but whether this is true for other …

Hereditary prostate cancer Page 1 Hereditary prostate cancer O. BRATT Department of Surgery,
Helsingborg Hospital, Helsingborg, Sweden Historical background and genetic principles …

Putative prostate cancer susceptibility loci have recently been identified by genetic linkage
analysis on chromosomes 1q24–25 (HPC1), 1q44. 2–43 (PCaP), and Xq27–28 (HPCX). In …

A previous linkage study provided evidence for a prostate cancer–susceptibility locus at
1q24-25. Subsequent reports in additional collections of families have yielded conflicting …

It is common belief that in families with hereditary prostate cancer (HPC), unaffected men
should be screened periodically with PSA, but little is known about the effects of such …

Prostate cancer is currently the most commonly diagnosed malignancy in American men.
Approximately 38,000 men die from this disease annually in this country (Boring et al. 1994) …

Multiple factors contribute to the high incidence and prevalence of prostate cancer including
race, ethnicity, diet, environment, widespread awareness through prostate-specific antigen …