miR‐34a‐5p Attenuates EMT through targeting SMAD4 in silica‐induced pulmonary fibrosis

Y Qi, A Zhao, P Yang, L Jin… - Journal of cellular and …, 2020 - Wiley Online Library
Silicosis is an incurable occupational disease, and its pathological feature is diffuse
pulmonary fibrosis. Pulmonary epithelial‐mesenchymal transition (EMT) is one of the …

MiR-503 modulates epithelial-mesenchymal transition in silica-induced pulmonary fibrosis by targeting PI3K p85 and is sponged by lncRNA MALAT1

W Yan, Q Wu, W Yao, Y Li, Y Liu, J Yuan, R Han… - Scientific Reports, 2017 - nature.com
Silicosis is a kind of chronic, progressive and incurable lung fibrotic diseases with largely
unknown and complex pathogenesis and molecular mechanisms. Mounting evidence …

miR-let-7d attenuates EMT by targeting HMGA2 in silica-induced pulmonary fibrosis

X Yu, R Zhai, B Hua, L Bao, D Wang, Y Li, W Yao… - RSC …, 2019 - pubs.rsc.org
Silicosis is a serious occupational disease characterized by pulmonary chronic inflammation
and progressive fibrosis. Epithelial-mesenchymal transition (EMT) of alveolar epithelial cells …

miR-489 inhibits silica-induced pulmonary fibrosis by targeting MyD88 and Smad3 and is negatively regulated by lncRNA CHRF

Q Wu, L Han, W Yan, X Ji, R Han, J Yang, J Yuan… - Scientific reports, 2016 - nature.com
Silicosis is an incurable occupational disease associated with inflammation, fibroblast
proliferation and the accumulation of extracellular matrix in lung tissues. The dysregulation …

MicroRNA-29b mediates lung mesenchymal-epithelial transition and prevents lung fibrosis in the silicosis model

J Sun, Q Li, X Lian, Z Zhu, X Chen, W Pei, S Li… - … Therapy-Nucleic Acids, 2019 - cell.com
Lung epithelial-mesenchymal transition (EMT) plays an important role in silicosis fibrosis.
The reverse process of EMT is mesenchymal-epithelial transition (MET), which is viewed as …

MiR-411–3p alleviates Silica-induced pulmonary fibrosis by regulating Smurf2/TGF-β signaling

X Gao, H Xu, D Xu, S Li, Z Wei, S Li, W Cai… - Experimental Cell …, 2020 - Elsevier
Occupational exposure to silica dust particles was the major cause of pulmonary fibrosis,
and many miRNAs have been demonstrated to regulate target mRNAs in silicosis. In the …

miR-542-5p attenuates fibroblast activation by targeting integrin α6 in silica-induced pulmonary fibrosis

J Yuan, P Li, H Pan, Y Li, Q Xu, T Xu, X Ji, Y Liu… - International Journal of …, 2018 - mdpi.com
Silicosis is a very serious occupational disease and it features pathological manifestations of
inflammatory infiltration, excessive proliferation of fibroblasts and massive depositions of the …

MiR‐503 suppresses fibroblast activation and myofibroblast differentiation by targeting VEGFA and FGFR1 in silica‐induced pulmonary fibrosis

Q Wu, L Han, W Gui, F Wang, W Yan… - Journal of cellular and …, 2020 - Wiley Online Library
Inhalation and deposition of crystalline silica particles in the lung can cause pulmonary
fibrosis, then leading to silicosis. Given the paucity of effective drugs for silicosis, new …

MiR-326 inhibits inflammation and promotes autophagy in silica-induced pulmonary fibrosis through targeting TNFSF14 and PTBP1

T Xu, W Yan, Q Wu, Q Xu, J Yuan, Y Li… - Chemical Research …, 2019 - ACS Publications
Silicosis is a kind of irreversible pulmonary fibrosis induced by the long-term inhalation of
silica particles. The therapeutic strategy based on the microRNAs might be an effective way …

MiR-449a regulates autophagy to inhibit silica-induced pulmonary fibrosis through targeting Bcl2

R Han, X Ji, R Rong, Y Li, W Yao, J Yuan, Q Wu… - Journal of Molecular …, 2016 - Springer
Silicosis is a fatal pulmonary fibrotic disorder characterized by accumulation of fibroblasts
and myofibroblasts and deposition of extracellular matrix proteins. MiR-449a is a potential …