Genomic rearrangements that give rise to oncogenic gene fusions can offer actionable
targets for cancer therapy. Here we present a systematic analysis of oncogenic gene fusions …

In cancer, fusions are important diagnostic markers and targets for therapy. Long-read
transcriptome sequencing allows the discovery of fusions with their full-length isoform …

RNA-sequencing and tailored bioinformatic methodologies have paved the way for
identification of expressed fusion genes from the chaotic genomes of solid tumors. We have …

Extensive investigation of gene fusions in cancer has led to the discovery of novel
biomarkers and therapeutic targets. To date, most studies have neglected chromosomal …

Fusion genes and fusion gene products are widely employed as biomarkers and therapeutic
targets in hematopoietic cancers, but their applications have yet to be appreciated in solid …

Background Gene fusions represent promising targets for cancer therapy in lung cancer.
Reliable detection of multiple gene fusions is therefore essential. Methods Five …