Introduction: Identifying the optimized dosing regimen and algorithm is critical in the
development of antibiotics. Suboptimal regimens and inappropriate choice of drug give rise …

Pharmacokinetics (PKs) in Japanese healthy subjects were simulated for nine compounds
using physiologically based PK (PBPK) models parameterized with physicochemical …

Purpose Estimating pharmacokinetic parameters in the presence of an endogenous
concentration is not straightforward as cross-reactivity in the analytical methodology …

Beta-lactams remain a critical member of our antibiotic armamentarium and are among the
most commonly prescribed antibiotic classes in the inpatient setting. For these agents, the …

Human pharmacokinetic (PK) predictions play a critical role in assessing the quality of
potential clinical candidates where the accurate estimation of clearance, volume of …

The use of in silico prediction of absorption, distribution, metabolism and excretion (ADME)
properties is gaining acceptance as a useful assessment tool for early identification of likely …

Pharmacokinetic models describe the absorption, distribution, metabolism and elimination of
toxicants of organism and provide a tool to relate the internal concentration of a toxicant at its …

Simplified physiologically based pharmacokinetic (PBPK) models using estimated tissue‐to‐
unbound plasma partition coefficients (Kpus) were previously investigated by fitting them to …

Abstract Background and Objective With the rise in the use of physiologically based
pharmacokinetic (PBPK) modeling over the past decade, the use of PBPK modeling to …

Oral drug absorption is a complex process depending on many factors, including the
physicochemical properties of the drug, formulation characteristics and their interplay with …