Association between augmented renal clearance and clinical outcomes in patients receiving β-lactam antibiotic therapy by continuous or intermittent infusion: a nested …
Augmented renal clearance (ARC) is known to influence β-lactam antibiotic
pharmacokinetics. This substudy of the BLING-II trial aimed to explore the association …
pharmacokinetics. This substudy of the BLING-II trial aimed to explore the association …
Principles and clinical application of assessing alterations in renal elimination pathways
SE Tett, CMJ Kirkpatrick, AS Gross… - Clinical …, 2003 - Springer
Drugs and metabolites are eliminated from the body by metabolism and excretion. The
kidney makes the major contribution to excretion of unchanged drug and also to excretion of …
kidney makes the major contribution to excretion of unchanged drug and also to excretion of …
Augmented renal clearance in traumatic brain injury: a single-center observational study of atrial natriuretic peptide, cardiac output, and creatinine clearance
Augmented renal clearance (ARC) is being increasingly described in neurocritical care
practice. The mechanisms driving this phenomenon are largely unknown. The aim of this …
practice. The mechanisms driving this phenomenon are largely unknown. The aim of this …
Pharmacokinetic changes in critical illness
Physiologic alterations are frequently evident in critically ill patients. These alterations can
significantly affect the pharmacokinetics of drugs used in this patient population …
significantly affect the pharmacokinetics of drugs used in this patient population …
[HTML][HTML] Clinical pharmacokinetics in kidney disease: application to rational design of dosing regimens
DM Roberts, J Sevastos, JE Carland… - Clinical Journal of the …, 2018 - journals.lww.com
A change in pharmacokinetics can alter drug exposure and predispose the patient to either
over-or underdosing, potentially resulting in adverse drug reactions or therapeutic failure …
over-or underdosing, potentially resulting in adverse drug reactions or therapeutic failure …
Drug absorption, distribution, metabolism and excretion considerations in critically ill adults
DJ Roberts, RI Hall - Expert opinion on drug metabolism & …, 2013 - Taylor & Francis
Introduction: All critically ill patients require medication to treat organ dysfunction. However,
the pharmacokinetics of drugs used to treat these patients is complex due to frequent …
the pharmacokinetics of drugs used to treat these patients is complex due to frequent …
Drug-associated renal dysfunction
SS Taber, BA Mueller - Critical care clinics, 2006 - criticalcare.theclinics.com
Methods The University of Michigan Health System (UMHS) is a tertiary care center with 865
licensed beds (550 adult, 206 pediatric). UMHS has 90 beds in six adult ICUs and 65 beds …
licensed beds (550 adult, 206 pediatric). UMHS has 90 beds in six adult ICUs and 65 beds …
Fluid overload in critically ill patients with acute kidney injury
J Cerda, G Sheinfeld, C Ronco - Blood purification, 2010 - karger.com
Fluid overload may occur in critically ill patients as a result of aggressive resuscitation
therapies. In such circumstances, persistent fluid overload must be avoided since it does not …
therapies. In such circumstances, persistent fluid overload must be avoided since it does not …
Guide to drug dosage in renal failure
WM Bennett - Clinical Pharmacokinetics, 1988 - Springer
The dosage of many drugs must be adjusted in patients with renal dysfunction to avoid
adverse reactions and to ensure efficacy. In addition, the biochemical abnormalities present …
adverse reactions and to ensure efficacy. In addition, the biochemical abnormalities present …
The effect of renal failure on hepatic drug clearance
MA Touchette, RL Slaughter - Dicp, 1991 - journals.sagepub.com
It is known that loss of renal function decreases the hepatic clearance of some drugs, but the
mechanisms by which this occurs are unclear. Knowledge of which drugs display reduced …
mechanisms by which this occurs are unclear. Knowledge of which drugs display reduced …