A guide to understanding antimicrobial drug dosing in critically ill patients on renal replacement therapy
V Pistolesi, S Morabito, F Di Mario… - Antimicrobial agents …, 2019 - Am Soc Microbiol
ABSTRACT A careful management of antimicrobials is essential in the critically ill with acute
kidney injury, especially if renal replacement therapy is required. Acute kidney injury may …
kidney injury, especially if renal replacement therapy is required. Acute kidney injury may …
Pharmacokinetic alterations associated with critical illness
D Morales Castro, L Dresser, J Granton, E Fan - Clinical Pharmacokinetics, 2023 - Springer
Haemodynamic, metabolic, and biochemical derangements in critically ill patients affect
drug pharmacokinetics and pharmacodynamics making dose optimisation particularly …
drug pharmacokinetics and pharmacodynamics making dose optimisation particularly …
PBPK modeling of the effect of reduced kidney function on the pharmacokinetics of drugs excreted renally by organic anion transporters
Altered pharmacokinetics (PK) in subjects with chronic kidney disease (CKD) may lead to
dosing adjustment of certain drugs in subjects with CKD. It can be valuable to quantitatively …
dosing adjustment of certain drugs in subjects with CKD. It can be valuable to quantitatively …
Drug dosing in chronic kidney disease
S Gabardi, S Abramson - Medical Clinics, 2005 - medical.theclinics.com
It is a well-known principle that endogenous creatinine clearance correlates well with the
renal elimination of most medications [1–4]. Be that as it may, it is a common oversight for …
renal elimination of most medications [1–4]. Be that as it may, it is a common oversight for …
Beta-lactam dosing in critically ill patients with septic shock and continuous renal replacement therapy
Although early and appropriate antibiotic therapy remains the most important intervention for
successful treatment of septic shock, data guiding optimization of beta-lactam prescription in …
successful treatment of septic shock, data guiding optimization of beta-lactam prescription in …
The complexities of interpreting reversible elevated serum creatinine levels in drug development: does a correlation with inhibition of renal transporters exist?
X Chu, K Bleasby, GH Chan, I Nunes, R Evers - Drug Metabolism and …, 2016 - ASPET
In humans, creatinine is formed by a multistep process in liver and muscle and eliminated
via the kidney by a combination of glomerular filtration and active transport. Based on …
via the kidney by a combination of glomerular filtration and active transport. Based on …
[HTML][HTML] Drug dosing in renal disease
MP Doogue, TM Polasek - The Clinical Biochemist Reviews, 2011 - ncbi.nlm.nih.gov
Renal disease alters the effects of many drugs, particularly when active drug moieties are
renally cleared. Drug doses should usually be reduced in renal disease in proportion to the …
renally cleared. Drug doses should usually be reduced in renal disease in proportion to the …
Increased β-Lactams dosing regimens improve clinical outcome in critically ill patients with augmented renal clearance treated for a first episode of hospital or …
C Carrié, G Chadefaux, N Sauvage, H de Courson… - Critical Care, 2019 - Springer
Background Augmented renal clearance (ARC) is recognized as a leading cause of β-
lactam subexposure when conventional dosing regimens are used. The main objective was …
lactam subexposure when conventional dosing regimens are used. The main objective was …
Current understanding of drug disposition in kidney disease
J Naud, TD Nolin, FA Leblond… - The Journal of Clinical …, 2012 - Wiley Online Library
Patients with chronic kidney disease (CKD) represent 13% of the American population. CKD
has been shown to significantly alter drug disposition of nonrenally eliminated drugs …
has been shown to significantly alter drug disposition of nonrenally eliminated drugs …