The glutamate homeostasis hypothesis of addiction
PW Kalivas - Nature reviews neuroscience, 2009 - nature.com
Addiction is associated with neuroplasticity in the corticostriatal brain circuitry that is
important for guiding adaptive behaviour. The hierarchy of corticostriatal information …
important for guiding adaptive behaviour. The hierarchy of corticostriatal information …
Glutamate transmission in addiction
Cortico-striatal glutamate transmission has been implicated in both the initiation and
expression of addiction related behaviors, such as locomotor sensitization and drug …
expression of addiction related behaviors, such as locomotor sensitization and drug …
New medications for drug addiction hiding in glutamatergic neuroplasticity
PW Kalivas, ND Volkow - Molecular psychiatry, 2011 - nature.com
The repeated use of drugs that directly or indirectly stimulate dopamine transmission carry
addiction liability and produce enduring pathological changes in the brain circuitry that …
addiction liability and produce enduring pathological changes in the brain circuitry that …
Role of nucleus accumbens glutamatergic plasticity in drug addiction
GC Quintero - Neuropsychiatric disease and treatment, 2013 - Taylor & Francis
Substance dependence is characterized by a group of symptoms, according to the
Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV …
Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV …
Astrocytic dysfunction and addiction: consequences of impaired glutamate homeostasis
MD Scofield, PW Kalivas - The Neuroscientist, 2014 - journals.sagepub.com
Addiction is characterized as a chronic relapsing disorder whereby addicted individuals
persistently engage in drug seeking and use despite profound negative consequences. The …
persistently engage in drug seeking and use despite profound negative consequences. The …
Glutamatergic mechanisms in addiction
TM Tzschentke, WJ Schmidt - Molecular psychiatry, 2003 - nature.com
Traditionally, addiction research in neuroscience has focused on mechanisms involving
dopamine and endogenous opioids. More recently, it has been realized that glutamate also …
dopamine and endogenous opioids. More recently, it has been realized that glutamate also …
The nucleus accumbens: mechanisms of addiction across drug classes reflect the importance of glutamate homeostasis
The nucleus accumbens is a major input structure of the basal ganglia and integrates
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …
Unmanageable motivation in addiction: a pathology in prefrontal-accumbens glutamate transmission
PW Kalivas, N Volkow, J Seamans - Neuron, 2005 - cell.com
Prime diagnostic criteria for drug addiction include uncontrollable urges to obtain drugs and
reduced behavioral responding for natural rewards. Cellular adaptations in the glutamate …
reduced behavioral responding for natural rewards. Cellular adaptations in the glutamate …
Plastic control of striatal glutamatergic transmission by ensemble actions of several neurotransmitters and targets for drugs of abuse
DM Lovinger, JG Partridge… - Annals of the New York …, 2003 - Wiley Online Library
Long‐lasting alterations in the efficacy of glutamatergic synapses, such as long‐term
potentiation (LTP) and long‐term depression (LTD), are prominent models for mechanisms …
potentiation (LTP) and long‐term depression (LTD), are prominent models for mechanisms …
Opioid and psychostimulant plasticity: targeting overlap in nucleus accumbens glutamate signaling
Commonalities in addictive behavior, such as craving, stimuli-driven drug seeking, and a
high propensity for relapse following abstinence, have pushed for a unified theory of …
high propensity for relapse following abstinence, have pushed for a unified theory of …