Stem cell-mediated gene delivering for the treatment of cerebral ischemia: progress and prospectives

C Chen, Y Wang, GY Yang - Current Drug Targets, 2013 - ingentaconnect.com
Ischemic stroke is one of the leading causes of death and disability worldwide. There is no
effective treatment for ischemic stroke apart from thrombolytic therapy, which has a narrow …

Mesenchymal stem cell therapy in stroke: a systematic review of literature in pre-clinical and clinical research

H Zheng, B Zhang, PY Chhatbar, Y Dong… - Cell …, 2018 - journals.sagepub.com
Exogenous stem cell therapy (SCT) has been recognized recently as a promising
neuroregenerative strategy to augment recovery in stroke survivors. Mesenchymal stem …

[HTML][HTML] Mesenchymal stem cell therapy in ischemic stroke trials. A systematic review

EM Gallego, MZ Castillo - Regenerative Therapy, 2024 - Elsevier
Cerebrovascular accidents, also known as strokes, are the leading cause of permanent
disability in society, presenting significant socioeconomic and healthcare costs. They can be …

Mesenchymal stromal cells rescue cortical neurons from apoptotic cell death in an in vitro model of cerebral ischemia

F Scheibe, O Klein, J Klose, J Priller - Cellular and molecular neurobiology, 2012 - Springer
Cell therapy with mesenchymal stromal cells (MSCs) was found to protect neurons from
damage after experimental stroke and is currently under investigation in clinical stroke trials …

[HTML][HTML] Attenuation of postischemic genomic alteration by mesenchymal stem cells: a microarray study

C Choi, SH Oh, JE Noh, YW Jeong, S Kim, JJ Ko… - Molecules and cells, 2016 - Elsevier
Intravenous administration of mesenchymal stem cells (IV-MSC) protects the ischemic rat
brain in a stroke model, but the molecular mechanism underlying its therapeutic effect is …

[PDF][PDF] Stand alone or join forces? Stem cell therapy for stroke

DI Abraham, M Gonzales, A Ibarra… - Expert Opin. Biol …, 2019 - researchgate.net
Introduction: Stroke is a major cause of mortality and disability with a narrow therapeutic
window. Stem cell therapy may enhance the stroke recovery. Areas Covered: Regenerative …

Human mesenchymal stromal cells and their derivative, SB623 cells, rescue neural cells via trophic support following in vitro ischemia

CC Tate, C Fonck, M McGrogan… - Cell …, 2010 - journals.sagepub.com
Cell transplantation is a promising treatment strategy for many neurological disorders,
including stroke, which can target multiple therapeutic mechanisms in a sustained fashion …

[HTML][HTML] MSC based gene delivery methods and strategies improve the therapeutic efficacy of neurological diseases

H Zhou, Y He, W Xiong, S Jing, X Duan, Z Huang… - Bioactive materials, 2023 - Elsevier
Mesenchymal stem cells (MSCs) are promising seed cells for neural regeneration therapy
owing to their plasticity and accessibility. They possess several inherent characteristics …

[HTML][HTML] Mesenchymal stem cell-based therapy for ischemic stroke

JD Anderson, MT Pham, Z Contreras, M Hoon… - Chinese Neurosurgical …, 2016 - Springer
Ischemic stroke represents a major, worldwide health burden with increasing incidence.
Patients affected by ischemic strokes currently have few clinically approved treatment …

Progress in mesenchymal stem cell therapy for ischemic stroke

Y Guo, Y Peng, H Zeng, G Chen - Stem cells international, 2021 - Wiley Online Library
Ischemic stroke (IS) is a serious cerebrovascular disease with high morbidity and disability
worldwide. Despite the great efforts that have been made, the prognosis of patients with IS …