Abstract Cytochrome P450-isoenzyme, CYP1A1, is responsible for the metabolic activation
of several precarcinogenic environmental chemicals to their carcinogenic intermediates …

Renal cell cancer is the main malignant tumour of the kidney and has an increasing
incidence. This type of tumour has a poor prognosis and shows intrinsic resistance to …

The presence of mRNA of individual members of the CYP1 gene family in normal and
neoplastic kidney has been investigated by RTPCR. CYP1B1 mRNA was consistently …

The hepatic cytochrome P4502A6 (CYP2A6) enzyme mediates the oxidative metabolism of
several procarcinogens that have liver as their primary target. Mouse models indicate that …

Renal cell carcinoma (RCC) is the most common malignancy of the kidney and has a poor
prognosis due to its late presentation and resistance to current anticancer drugs. One …

Background: Cytochrome P-450 4A11 (CYP4A11) and peroxisome proliferator-activated
receptor-α (PPARα) are expressed at high levels in renal proximal tubules, and upregulation …

The progressive increase in sporadic renal cell carcinoma (RCC) observed in industrialized
countries supports the opinion that certain carcinogens present in the environment (tobacco …

As carcinogenesis is a process starting at the single-cell level it is desirable to study
carcinogen-mediated effects in individual cells. A primary step in chemically induced …

A new P450 responsible for mutagenic activation of 3-methoxy-4-aminoazobenzene (3-MeO-
AAB) which is a potent procarcinogen was purified from renal microsomes of male mice …

Abstract Cytochrome P450 2E1 (CYP2E1) is known as a heme-containing enzyme that
produces abundant free radicals, and its involvement in carcinogenesis has been suggested …