We have shown previously that activation of the heme oxygenase-1 (ho-1) gene by hypoxia
in aortic smooth muscle cells is mediated by hypoxia-inducible factor-1 (HIF-1). In mutant …

Exposure of rats to hypoxia (7% O 2) markedly increased the level of heme oxygenase-1
(HO-1) mRNA in several tissues. Accumulation of HO-1 transcripts was also observed after …

Stress response elements, which mediate induction of the mouse heme oxygenase-1 (HO-1)
gene by several agents, resemble the binding site for the activator protein-1 (Jun/Fos), Maf …

Heme oxygenase-1 (HO-1) is induced by oxidative stress and plays an important role in
cellular protection against oxidant injury. Increasing evidence also suggests that HO-1 is …

The endothelium of the lung is sensitive to the toxic effects of oxygen, and early evidence of
toxicity is characterized by protein leak and extravasation of red blood cells. The …

We have previously shown marked induction of the stress-inducible gene heme oxygenase-
1 (HO-1) in vivo and in vitro after hyperoxia. In RAW 264.7 cells, HO-1 induction is …

Heme oxygenase 1 (HO-1), a rate-limiting enzyme in heme catabolism, has been reported to
be induced by hypoxia. Unexpectedly, here we show that expression of HO-1 mRNA is …

Using hyperoxia as a model of oxidant-induced lung injury in the rat, we explored the
regulation of heme oxygenase-1 (HO-1) expression in vivo and in vitro. We demonstrate …

ABSTRACT Heme oxygenase 1 (HO‐1), a stress response protein, is highly induced in
response to various agents causing oxidative stress including ultraviolet irradiation, sodium …

The hypoxia-inducible factor (HIF) activates the expression of genes that contain a hypoxia
response element (HRE). The alpha subunit of the HIF transcription factors is degraded by …