Disturbances of intracellular redox equilibrium may alter eukaryotic gene expression
patterns in the manifestation of an adaptive stress response. The inducible heme oxygenase …

The mechanism of heme oxygenase-1 (ho-1) gene activation by arsenite was examined.
Arsenite-stimulated expression of a ho-1 promoter/luciferase chimera in a dose-dependent …

It has been proposed that cells sense hypoxia by a heme protein, which transmits a signal
that activates the heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) …

Heme oxygenase-1 (HO-1) catalyzes the rate-limiting step in heme degradation, releasing
iron, carbon monoxide, and biliverdin. Induction of HO-1 is an adaptive and beneficial …

Heme oxygenase 1 (HO-1) catalyzes heme breakdown, eventually releasing iron, carbon
monoxide, and bilirubin IXα. HO-1 is induced by its substrate heme and various …

The mouse heme oxygenase-1 (HO-1) gene, ho-1, contains two inducible enhancers, E1
and E2. Of several cell lines tested, induction of an E1/luciferase fusion construct, pE1-luc …

The hypoxia-inducible factor (HIF) activates the expression of genes that contain a hypoxia
response element. The α-subunits of the HIF transcription factors are degraded by …

Mouse genomic fragments encoding heme oxygenase-1 (HO-1) were isolated from a
recombinant lambda library by in situ plaque hybridization. The mouse HO-1 gene …

Heme oxygenase (HO)-1 is a stress response protein, which confers cytoprotection against
oxidative injury and provides a vital function in maintaining tissue homeostasis. Molecular …

The stress protein heme oxygenase-1 (HO-1) is induced in endothelial cells exposed to
nitric oxide (NO)-releasing agents, and this process is finely modulated by thiols (Foresti, R …