What are the roles of the many different types of potassium channel expressed in cerebellar granule cells?

A Mathie, CE Clarke, KM Ranatunga, EL Veale - The Cerebellum, 2003 - Springer
Potassium (K) channels have a key role in the regulation of neuronal excitability. Over a
hundred different subunits encoding distinct K channel subtypes have been identified so far …

Identification of native rat cerebellar granule cell currents due to background K channel KCNK5 (TASK-2)

JF Cotten, HL Zou, C Liu, JD Au, CS Yost - Molecular brain research, 2004 - Elsevier
The TWIK-related, Acid Sensing K (TASK-2; KCNK5) potassium channel is a member of the
tandem pore (2P) family of potassium channels and mediates an alkaline pH-activated, acid …

Characterization of four types of background potassium channels in rat cerebellar granule neurons

J Han, J Truell, C Gnatenco, D Kim - The Journal of Physiology, 2002 - Wiley Online Library
Cerebellar granule neurons express a standing outward (background) K+ current (IK, SO)
that regulates the resting membrane potential and cell excitability. As several tandem‐pore …

A functional role for the two-pore domain potassium channel TASK-1 in cerebellar granule neurons

JA Millar, L Barratt, AP Southan… - Proceedings of the …, 2000 - National Acad Sciences
Cerebellar granule neurons (CGNs) are one of the most populous cells in the mammalian
brain. They express an outwardly rectifying potassium current, termed a “standing-outward” …

Differential expression of two-pore domain potassium channels in rat cerebellar granule neurons

P Burgos, R Zúñiga, P Domínguez… - Biochemical and …, 2014 - Elsevier
Two pore domain potassium (K2P) channels are mostly present in the central nervous
system (CNS) where they play important roles in modulating neuronal excitability. K2P …

Ternary Kv4.2 channels recapitulate voltage‐dependent inactivation kinetics of A‐type K+ channels in cerebellar granule neurons

Y Amarillo, JA De Santiago‐Castillo… - The Journal of …, 2008 - Wiley Online Library
Kv4 channels mediate most of the somatodendritic subthreshold operating A‐type current
(ISA) in neurons. This current plays essential roles in the regulation of spike timing, repetitive …

Identification and characterization of Cs+‐permeable K+ channel current in mouse cerebellar Purkinje cells in lobules 9 and 10 evoked by molecular layer …

H Ishii, K Nakajo, Y Yanagawa… - European Journal of …, 2010 - Wiley Online Library
The mouse cerebellum consists of 10 lobules, which are distinguishable by their anatomical
and functional properties. However, the differences in the slow postsynaptic currents …

Novel subcellular distribution pattern of A-type K+ channels on neuronal surface

M Kollo, NB Holderith, Z Nusser - Journal of Neuroscience, 2006 - Soc Neuroscience
Potassium channels comprise the most diverse family of ion channels. In nerve cells, their
critical roles in synaptic integration and output generation have been demonstrated. Here …

KCR1, a membrane protein that facilitates functional expression of non-inactivating K+ currents associates with rat EAG voltage-dependent K+ channels

N Hoshi, H Takahashi, M Shahidullah… - Journal of Biological …, 1998 - ASBMB
Cerebellar granule neurons possess a non-inactivating K+ current, which controls resting
membrane potentials and modulates the firing rate by means of muscarinic agonists. kcr1 …

Voltage gated potassium channels: Structure and function of Kv1 to Kv9 subfamilies

B Rudy, J Maffie, Y Amarillo, B Clark… - Encyclopedia of …, 2009 - pure.psu.edu
The nervous system contains a large diversity of potassium channels, the membrane
proteins that regulate the movement of potassium ions across the cell membrane. All …