Microcirculatory dysfunction has been recently recognized as a key pathophysiologic
process in the evolution of sepsis. In the present review, we discuss fundamental aspects of …

Abnormal microvascular perfusion, including decreased functional capillary density and
increased blood flow heterogeneity, is observed in early stages of the systemic inflammatory …

Microvascular alterations are a hallmark of sepsis and play a crucial role in its
pathophysiology. Such alterations are the result of overwhelming inflammation, which …

The microcirculation describes the smallest elements of the cardiovascular conducting
system and is pivotal in the maintenance of homeostasis. Microcirculatory dysfunction is …

Multiple experimental and human trials have shown that microcirculatory alterations are
frequent in sepsis. In this review, we discuss the characteristics of these alterations, the …

Largely ignored throughout the history of clinical medicine, the microcirculation has recently
been recognized at the bedside as the center of several pathophysiological processes …

Multiple experimental and human trials have shown that microcirculatory alterations are
frequent in sepsis. In this review, we discuss the various mechanisms that are potentially …

Sepsis is the number one cause of death among critically ill patients and accounts for more
than 215,000 deaths every year in the United States alone. 1, 2 Randomized controlled trials …

Microcirculatory perfusion is disturbed in sepsis. Recent research has shown that
maintaining systemic blood pressure is associated with inadequate perfusion of the …

Microcirculatory dysfunction plays a pivotal role in the pathogenesis of severe sepsis and
septic shock; hence, microcirculation blood flow monitoring has gained increasing attention …