Antifungal drug discovery: new theories and new therapies

CJ Seneviratne, EAR Rosa - Frontiers in microbiology, 2016 - frontiersin.org
Medically important fungal infections can be broadly classified into superficial surface
infections and invasive mycoses (Samaranayake and MacFarlane, 1990; Roemer and …

Antifungal drug development: challenges, unmet clinical needs, and new approaches

T Roemer, DJ Krysan - Cold Spring …, 2014 - perspectivesinmedicine.cshlp.org
Invasive, life-threatening fungal infections are an important cause of morbidity and mortality,
particularly for patients with compromised immune function. The number of therapeutic …

Progress in antifungal drug discovery

MB Anderson, T Roemer, R Fabrey - 2003 - Elsevier
Undoubtedly, innovative research efforts will continue in the 21 st century as we seek to
minimize the incidence of opportunistic fungal infections worldwide, exploit available and …

New drugs and other strategies for the treatment of fungal infections

R Almeida-Paes, S Frases - Future Microbiology, 2023 - Taylor & Francis
The field of medical science has long been engaged in a relentless war against microbial
foes, seeking innovative strategies and treatments to combat the ever-evolving threats they …

Potential targets for the development of new antifungal drugs

H Su, L Han, X Huang - The journal of antibiotics, 2018 - nature.com
In recent years, incidences of invasive fungal infections have greatly increased, especially in
immunosuppressed patients, but most today's antifungal drugs are not completely effective …

Antifungal drug discovery: something old and something new

A Butts, DJ Krysan - 2012 - journals.plos.org
Invasive fungal infections are devastating. Despite state-of-theart antifungal therapy, the
mortality rates for invasive infections with the three most common species of human fungal …

Advances in antifungal development: Discovery of new drugs and drug repurposing

JH Kim, LW Cheng, KM Land - Pharmaceuticals, 2022 - mdpi.com
This Special Issue of Pharmaceuticals describes recent advances accomplished in the field
of antifungal development, especially the discovery of new drugs and drug repurposing. The …

Antifungal drugs: the current armamentarium and development of new agents

N Robbins, GD Wright, LE Cowen - Microbiology spectrum, 2016 - Am Soc Microbiol
Invasive fungal infections are becoming an increasingly important cause of human mortality
and morbidity, particularly for immunocompromised populations. The fungal pathogens …

Current research and new perspectives in antifungal drug development

I Oltu, L Cepoi, V Rudic, L Rudi, T Chiriac… - … , infectious diseases and …, 2020 - Springer
In recent times, fungi are becoming more and more active as causal agents of human
infections, which is primarily determined by the growing number of people with severe …

Recent progress on antifungal drug development

B Zhai, X Lin - Current pharmaceutical biotechnology, 2011 - ingentaconnect.com
Invasive fungal infections are a serious threat to public health, particularly to people with
compromised or suppressed immunity. Although the current antifungal therapies have been …