Mice deficient in the IL-10 pathway are the most widely used models of intestinal
immunopathology. IL-17A is strongly implicated in gut disease in mice and humans, but …

Background IL-23/TH17 inflammatory responses are regarded as central to the
pathogenesis of inflammatory bowel disease, but clinically IL-17A antibodies have shown …

Background & Aims: Interleukin (IL)-21, a T-cell-derived cytokine, is overproduced in
inflammatory bowel diseases (IBD), but its role in the pathogenesis of gut inflammation …

In the IL-17 family of cytokines, much is known about the sources and functions of IL-17, IL-
17F, and IL-25 in the host defense against infection and in inflammatory diseases; however …

Results of experimental and genetic studies have highlighted the role of the IL-23/IL-17 axis
in the pathogenesis of inflammatory bowel disease (IBD). IL-23–driven inflammation has …

Abstract Interleukin 23 (IL-23) and IL-17 have been linked to the pathogenesis of several
chronic inflammatory disorders, including inflammatory bowel disease. Yet as an important …

IL-10 is an immune regulatory cytokine and its genetic defect leads to gastrointestinal
inflammation in humans and mice. Moreover, the IL-23/Th17 axis is known to be involved in …

Uncontrolled mucosal immunity in the gastrointestinal tract of humans results in chronic
inflammatory bowel disease (IBD), such as Crohn disease and ulcerative colitis. In early …

BACKGROUND & AIMS:: The cytokine interleukin (IL)-10 is required to maintain immune
homeostasis in the gastrointestinal tract. IL-10 null mice spontaneously develop colitis or are …

Background & Aims: Interleukin (IL)-23 supports a distinct lineage of T cells producing IL-17
(Th17) that can mediate chronic inflammation. This study was performed to define the role of …