3D-QSAR and Molecular Docking Studies on Fused Pyrazoles as p38α Mitogen-Activated Protein Kinase Inhibitors
WM Chen, JR Sun, ZJ Huang, P Lan - 2010 - agris.fao.org
The p38α mitogen-activated protein kinase (MAPK) has become an attractive target for the
treatment of many diseases such as rheumatoid arthritis, inflammatory bowel disease and …
treatment of many diseases such as rheumatoid arthritis, inflammatory bowel disease and …
[PDF][PDF] IN SILLICO STUDY OF ACTIVE COMPOUNDS OF RAMANIA LEAF EXTRACTS (Bouea macrophylla Griffth) ON PROTEIN KINASE C-β
T Irham - seybold-report.com
Abstract Background: Traumatic Dental Injury (TDI) causes injury to the teeth and tissues
around the oral cavity. A total of 17.2% incidence of TDI in children and adolescents under …
around the oral cavity. A total of 17.2% incidence of TDI in children and adolescents under …
Identification of benzimidazole containing 4H–chromen–4–one derivative as potential MAP kinase inhibitors by in-silico approaches
K Lakshmanan, G Byran - Journal of Receptors and Signal …, 2021 - Taylor & Francis
MAP kinase is one of the important targets in the treatment of osteoarthritis, inflammation
and cancer. Many p38 inhibitors with diverse chemical structures and modes of protein …
and cancer. Many p38 inhibitors with diverse chemical structures and modes of protein …
[HTML][HTML] Insights into features and lead optimization of novel type 1½ inhibitors of p38α mitogen-activated protein kinase using QSAR, quantum mechanics, bioisostere …
IY Joel, TO Adigun, OO Bankole, MA Iduze… - Results in …, 2020 - Elsevier
Abstract p38α mitogen-activated protein kinase (p38αMAPK) has been implicated in many
diseases yet no inhibitor has been approved for therapeutic use. Various inhibitors have …
diseases yet no inhibitor has been approved for therapeutic use. Various inhibitors have …
In silico pathway analysis of MAPKs and computational investigation of bipyrazole analogues as novel p38alpha MAPK inhibitors
D Nedunuri, Y Adimulam… - International Journal of …, 2016 - inderscienceonline.com
Mitogen-Activated Protein Kinase (MAPK) belongs to one of the largest super-families of
proteins. The activity of most MAPKs is stimulated by a large variety of signals, including …
proteins. The activity of most MAPKs is stimulated by a large variety of signals, including …
[HTML][HTML] In silico target identification and validation for antioxidant and anti-inflammatory activity of selective phytochemicals.
Phytochemicals present in plant extract include a number of biological active compounds
which have shown promising antioxidant and anti-inflammatory activities in many animal …
which have shown promising antioxidant and anti-inflammatory activities in many animal …
[PDF][PDF] Structural diversity and role of phytochemicals against p38-α Mitogen-Activated Protein Kinase and Epidermal Growth Factor Receptor Kinase domain: A …
A Shankar, SM Gopinath, SP Kollur… - Journal of Pure and …, 2021 - academia.edu
Computational databases and tools in recent times have been proved to provide an
essential aid for anticancer studies in the field of oncology. Molecular docking studies …
essential aid for anticancer studies in the field of oncology. Molecular docking studies …
[PDF][PDF] Molecular Properties and Docking Studies on Chromone Pyrazolones as Potential Inhibitors of P38 Map Kinase
PP Vikhe, RB Gaikar, GP Vikhe, RJ Meshram… - Int J Pharm Pharm …, 2011 - researchgate.net
The p38 mitogen-activated protein (MAP) kinase plays important role in inflammatory
response. Inhibitors of the p38 MAP Kinase can offer effective treatment for the inflammatory …
response. Inhibitors of the p38 MAP Kinase can offer effective treatment for the inflammatory …
[HTML][HTML] Design and Synthesis of Novel 1-hydroxy-2, 4, 5-triaryl Imidazole Derivatives as Anti-cytokine Agents
Among recent advances in the identification of anti-inflammation agents, anti-cytokines (like
Interleukin-1), related to p38 MAPK families play an important role; Here in we designed …
Interleukin-1), related to p38 MAPK families play an important role; Here in we designed …