In the adult mammalian brain, glial cells, to a much greater extent than neurons, express the
intriguing form of intercellular communication that is mediated by gap junctions 1, 2 (see …

Inwardly rectifying potassium (Kir) channels have long been regarded as transmembrane
proteins that regulate the membrane potential of neurons and that are responsible for [K+] …

Although K+ channels activated by Ca 2+ have long been known to shape neuronal
excitability, evidence is accumulating that K+ channels sensitive to intracellular Na+, termed …

The neuronal K-Cl cotransporter isoform (KCC2) was functionally expressed in human
embryonic kidney (HEK-293) cell lines. Two stably transfected HEK-293 cell lines were …

In the present study, we have demonstrated functional interaction between Ste20-related
proline-alanine-rich kinase (SPAK), WNK4 [with no lysine (K)], and the widely expressed …

Heteromeric KCNQ2/3 potassium channels are thought to underlie the M-current, a
subthreshold potassium current involved in the regulation of neuronal excitability. KCNQ …

Neuronal stimulation causes∼ 30% shrinkage of the extracellular space (ECS) between
neurons and surrounding astrocytes in grey and white matter under experimental conditions …

Glia use multiple mechanisms to mediate potassium fluxes that support neuronal function. In
addition to changes in potassium levels within synapses, these ions are dynamically …

A number of mechanisms have been proposed to play a role in the regulation of activity-
dependent variations in extracellular potassium concentration ([K+] o). We tested possible …

Astrocytic Kir4. 1 channels and spatial potassium buffering: Astrocytes play a crucial role in
maintaining the structural and functional integrity of the brain, which includes formation of …