American Diabetes Association (ADA), San Francisco, June 2002, Jeffrey Flier (Boston, MA)
discussed the effects of visceral obesity. While reviewing the differing components of the …

It has been known for over half a cen-tury that accumulation of fat in the upper body is
associated with metabolic complications of obesity. The mechanism responsible for this …

CENTRAL OBESITY-J. Vague (9) first documented central obesity as an adverse health
factor in the early 1950s when he described the android and gynoid forms of obesity …

Obesity is well known to be associated with insulin resistance and consequential
hyperinsulinemia [1, 2]. Moreover, further worsening of insulin resistance and greater …

The association of obesity with type 2 diabetes has been recognized for decades, and the
major basis for this link is the ability of obesity to engender insulin resistance. Insulin …

Insulin resistance is the cornerstone for the development of non-insulin-dependent diabetes
mellitus (NIDDM). Free fatty acids (FFAs) cause insulin resistance in muscle and liver and …

Body fat distribution can be assessed by computed tomography (CT). The ratio of umbilicus
was used to classify obese subjects as having visceral fat obesity (VFO) or subcutaneous fat …

311–377, 1974 3. Muntoni S: Metformin and fatty acids. Diabetes Care 22: 179–180, 1999 4.
Fischer Y, Thomas J, Rosen P, Kammermeier H: Action of metformin on glucose transporter …

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prohibited. showed that insulin resistance is important, but not responsible alone for the …

At a symposium addressing the relationships between obesity, hypertension, and
cardiovascular disease at the ASH, Roger Unger (Dallas, TX) discussed lipotoxicity and the …