Autophagy is the principal cellular pathway for degradation of long-lived proteins and
organelles and regulates cell fate in response to stress. Recently, autophagy has been …

Beclin 1 is a protein involved in the regulation of autophagy and has been shown to be
reduced in patients with Alzheimer disease. This review summarizes the current research …

Autophagy is an intracellular degradation pathway that functions in protein and organelle
turnover in response to starvation and cellular stress. Autophagy is initiated by the formation …

Impairment of the autophagy pathway has been observed during the pathogenesis of
Alzheimer's disease (AD), a neurodegenerative disorder characterized by abnormal …

Autophagy, a bulk degradation of subcellular constituents, is activated in normal cell growth
and development, and represents the major pathway by which the cell maintains a balance …

The accumulation of amyloid-β-containing neuritic plaques and intracellular tau protein
tangles are key histopathological hallmarks of Alzheimer's disease (AD). This type of …

The Beclin-1 protein is essential for the initiation of autophagy, and recent studies suggest
this function may be compromised in Alzheimer's disease (AD). In addition, in vitro studies …

Autophagy is a highly regulated cellular mechanism for the bulk degradation of cytoplasmic
contents which seems to be implicated in a variety of physiological and pathological …

Autophagy is a degradation of the cytoplasm and it induces autophagic cell death in several
neurodegenerative conditions. Beclin 1, a Bcl-2-interacting protein, is known to be a …

Beclin 1 is the first mammalian autophagy protein identified as a novel Bcl-2-interacting
protein. Subsequent studies have demonstrated that this landmark protein is essential for …