Connexins had been considered to be the only class of the vertebrate proteins capable of
gap junction formation; however, new candidates for this function with no homology to …

Gap junctions (GJs) are composed of proteins that form a channel connecting the cytoplasm
of adjacent cells. Connexins were initially considered to be the only proteins capable of GJ …

Pannexin (Panx) 1 is a widely expressed protein that shares structural, but not amino acid,
homology with gap junction proteins, the connexins. Panx1 does not form gap junctions in …

The mammalian pannexin family of channel‐forming proteins consisting of Panx1, Panx2,
and Panx3 has received considerable attention in the last 10 years given their newly …

Until recently, members of the connexin gene family were believed to comprise the sole
molecular component forming gap junction channels in vertebrates. The recent discovery of …

Pannexin2 (Panx2) is the largest of three members of the pannexin proteins. Pannexins are
topologically related to connexins and innexins, but serve different functional roles than …

Pannexins (Panx) are proteins with a similar membrane topology to connexins, the integral
membrane protein of gap junctions. Panx1 channels are generally of major importance in a …

Pannexins, large non-gap junction super family exists in vertebrates, play multiple roles in
different cellular functions through their ATP release. Panx1-mediated adenosine 5 …

Abstract Pannexin‑1 (Panx‑1) is abundantly expressed in vertebrates and has been shown
to assemble into high‑conductance single‑membrane channels, which are permeable to …

Pannexins constitute a family of proteins exhibiting predominantly hemichannel activity.
Pannexin channels have been suggested to participate in a wide spectrum of biological …