Reactive oxygen species (ROS) play a key role in the neurodegeneration processes.
Increased oxidative stress damages lipids, proteins, and nucleic acids in brain tissue, and it …

Iron is a crucial transition metal for life and is the most abundant transition metal in the brain.
However, iron's biological utility as an effective redox cycling metal also endows it with the …

Iron overload is a hallmark of many neurodegenerative processes such as Alzheimer's,
Parkinson's, and Huntington's diseases. Unbound iron accumulated as a consequence of …

Iron is both essential for maintaining a spectrum of metabolic processes in the central
nervous system and elsewhere, and potent source of reactive oxygen species. Redox …

The dysregulation of iron metabolism in Alzheimer's disease is not accounted for in the
current framework of the amyloid cascade hypothesis. Accumulating evidence suggests that …

Although iron is essential in maintaining the function of the central nervous system, it is a
potent source of reactive oxygen species. Excessive iron accumulation occurs in many …

Free radical formation, abnormalities in iron and copper distribution, and metal-catalyzed
oxidation have all been noted in Alzheimer disease and are thought to play an important …

Alzheimer's disease (AD) is a multifactorial neurodegenerative condition associated with
pathological accumulation of amyloid plaques and with the appearance of deposit of …

Iron plays a crucial role in many physiological processes of the human body, but iron is
continuously deposited in the brain as we age. Early studies found iron overload is directly …

Many lines of evidence indicate that oxidative stress is one of the earliest events in the
genesis of Alzheimer's disease (AD). Iron is a transition metal capable of generating …