Background Primaquine is used to eliminate Plasmodium vivax hypnozoites, but its optimal
dosing regimen remains unclear. We undertook a systematic review and individual patient …

Background Chloroquine remains the mainstay of treatment for Plasmodium vivax malaria
despite increasing reports of treatment failure. We did a systematic review and meta …

Background Primaquine radical cure is used to treat dormant liver-stage parasites and
prevent relapsing Plasmodium vivax malaria but is limited by concerns of haemolysis. We …

Summary Background Prevention of Plasmodium vivax malaria recurrence is essential for
malaria elimination in Brazil. We evaluated the real-world effectiveness of an updated …

Background In most of the Americas, the recommended treatment to prevent relapse of
Plasmodium vivax malaria is primaquine at a total dose of 3.5 mg per kilogram of body …

Background Artemisinin-based combination therapy (ACT) is recommended for
uncomplicated Plasmodium vivax malaria in areas of emerging chloroquine resistance. We …

Background A 14-day course of primaquine is used for radical cure of Plasmodium vivax
and Plasmodium ovale malaria only. We quantified the risk of P vivax parasitaemia after …

Background Recent efforts in malaria control have resulted in great gains in reducing the
burden of Plasmodium falciparum, but P. vivax has been more refractory. Its ability to form …

Plasmodium vivax and Plasmodium ovale form dormant liver hypnozoites that can reactivate
weeks to months following initial infection. Malaria recurrences caused by relapses are an …

Introduction Recurrent P. vivax infections are associated with significant morbidity and
mortality. Although radical cure can reduce recurrent infection, it is confounded by …