Mibefradil is a Ca2+ channel antagonist that inhibits both T-type and high-voltage-activated
Ca2+ channels. We previously showed that block of high-voltage-activated channels by …

ABSTRACT NNC 55‐0396 is a structural analog of mibefradil (Ro 40‐5967) that inhibits
both T‐type and high‐voltage‐activated (HVA) Ca2+ channels with a higher selectivity for T …

The voltage gated calcium channel family is a major target for a range of therapeutic drugs.
Mibefradil (Ro 40–5967) belongs to a new chemical class of these molecules which differs …

We compared detailed efficacy of efonidipine and nifedipine, dihydropyridine analogues,
and mibefradil using recombinant T-and L-type Ca2+ channels expressed separately in …

Ca 2+ channel antagonists of the dihydropyridine, benzothiazepine, and phenylalkylamine
classes have selective effects on L-type versus T-type Ca 2+ channels. In contrast …

Mibefradil is a novel Ca2+ antagonist which blocks both high‐voltage activated and low
voltage‐activated Ca2+ channels. Although L‐type Ca2+ channel block was demonstrated …

Mibefradil is a tetralol derivative chemically distinct from other calcium channel antagonists.
It is a very effective antihypertensive agent that is thought to achieve its action via a higher …

In contrast to other kinds of voltage-gated Ca2+ channels, the underlying molecular basis of
T-type and R-type channels is not well-understood. To facilitate comparisons with cloned …

Mibefradil is a novel Ca2+ antagonist acting on both L-and T-type Ca2+ channels, with a ten-
fold selectivity for T-type Ca2+ channels. It belongs to a chemical class different from other …

It has been shown that mibefradil (Ro 40-5967) exerts a selective inhibitory effect on T-type
Ca2+ currents, although at higher concentrations it can antagonize high voltage-activated …