Multiple sclerosis (MS) is an immune-driven demyelinating disease of the central nervous
system. Immune cell features are particularly promising as predictive biomarkers due to their …

Multiple sclerosis (MS) is an inflammatory demyelinating and neurodegenerative disease of
the central nervous system (CNS). Studies in rodent models demonstrated an association of …

Current understanding of Multiple Sclerosis (MS) pathophysiology implicates perturbations
in adaptive cellular immune responses, predominantly T cells, in Relapsing-Remitting forms …

Background In a subgroup of patients suffering from progressive multiple sclerosis (MS),
which is an inflammation-mediated neurodegenerative disease of the central nervous …

Multiple sclerosis (MS) is a chronic and often disabling autoimmune disease of the central
nervous system (CNS). Cerebrospinal fluid (CSF) surrounds and protects the CNS. Analysis …

Multiple sclerosis (MS) is an immune mediated, inflammatory and demyelinating disease of
the central nervous system (CNS). Substantial evidence points toward monocytes and …

Background There is accumulating evidence from immunological, pathological and
therapeutic studies that B cells are key components in the pathophysiology of multiple …

Peripheral central nervous system (CNS)–infiltrating lymphocytes are a hallmark of
relapsing-remitting multiple sclerosis. Tissue-resident memory T cells (TRM) not only …

Multiple sclerosis is an inflammatory demyelinating disease in which active demyelination
and neurodegeneration are associated with lymphocyte infiltrates in the brain. However, so …

Clinical trial results of peripheral B cell depletion indicate abnormal proinflammatory B cell
properties, and particularly antibody-independent functions, contribute to relapsing MS …