Micro-scaffold array chip for upgrading cell-based high-throughput drug testing to 3D using benchtop equipment
Cell-based high throughput drug screening accelerates the pace of drug discovery which is
routinely operated on planar high-density multi-well plates with sophisticated robotic liquid …
routinely operated on planar high-density multi-well plates with sophisticated robotic liquid …
A microfluidic-based platform for tumour spheroid culture, monitoring and drug screening
K Kwapiszewska, A Michalczuk, M Rybka… - Lab on a Chip, 2014 - pubs.rsc.org
The development of novel cellular models that can replace animals in preclinical trials of
drug candidates is one of the major goals of cell engineering. Current in vitro screening …
drug candidates is one of the major goals of cell engineering. Current in vitro screening …
Microengineering methods for cell-based microarrays and high-throughput drug-screening applications
Screening for effective therapeutic agents from millions of drug candidates is costly, time
consuming, and often faces concerns due to the extensive use of animals. To improve cost …
consuming, and often faces concerns due to the extensive use of animals. To improve cost …
Unified 2D and 3D cell-based high-throughput screening platform using a micropillar/microwell chip
DW Lee, IL Doh, DH Nam - Sensors and Actuators B: Chemical, 2016 - Elsevier
A unified high-throughput screening (HTS) platform is proposed for both 2D and 3D cell
culture models in a single chip platform. Comparison studies between well-established 2D …
culture models in a single chip platform. Comparison studies between well-established 2D …
Simple droplet microfluidics platform for drug screening on cancer spheroids
C Parent, KR Melayil, Y Zhou, V Aubert, D Surdez… - Lab on a Chip, 2023 - pubs.rsc.org
3D in vitro biological systems are progressively replacing 2D systems to increase the
physiological relevance of cellular studies. Microfluidics-based approaches can be powerful …
physiological relevance of cellular studies. Microfluidics-based approaches can be powerful …
Multilayer architecture microfluidic network array for combinatorial drug testing on 3D-cultured cells
In vitro testing of drug compounds on cell models during the drug development process
represents an indispensable step in the initial screening process. Although drug testing on …
represents an indispensable step in the initial screening process. Although drug testing on …
A fully 3D-printed versatile tumor-on-a-chip allows multi-drug screening and correlation with clinical outcomes for personalized medicine
E Steinberg, R Friedman, Y Goldstein… - Communications …, 2023 - nature.com
Optimal clinical outcomes in cancer treatments could be achieved through the development
of reliable, precise ex vivo tumor models that function as drug screening platforms for patient …
of reliable, precise ex vivo tumor models that function as drug screening platforms for patient …
A microfluidic spheroid culture device with a concentration gradient generator for high-throughput screening of drug efficacy
Three-dimensional (3D) cell culture is considered more clinically relevant in mimicking the
structural and physiological conditions of tumors in vivo compared to two-dimensional cell …
structural and physiological conditions of tumors in vivo compared to two-dimensional cell …
Simultaneous culturing of cell monolayers and spheroids on a single microfluidic device for bridging the gap between 2D and 3D cell assays in drug research
Abstract Two‐dimensional (2D) cell cultures have been the primary screening tools to
predict drug impacts in vitro for decades. However, owing to the lack of tissue‐specific …
predict drug impacts in vitro for decades. However, owing to the lack of tissue‐specific …
Characterising a PDMS based 3D cell culturing microfluidic platform for screening chemotherapeutic drug cytotoxic activity
Abstract Three-dimensional (3D) spheroidal cell cultures are now recognised as better
models of cancers as compared to traditional cell cultures. However, established 3D cell …
models of cancers as compared to traditional cell cultures. However, established 3D cell …