Chondrocyte apoptosis: a cause or consequence of osteoarthritis?

Z Zamli, M Sharif - International journal of rheumatic diseases, 2011 - Wiley Online Library
Osteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage
degradation and changes in the subchondral bone. Over the last two decades, there has …

Chondrocyte death by apoptosis is associated with the initiation and severity of articular cartilage degradation

CM Thomas, CJ Fuller, CE Whittles… - International journal of …, 2011 - Wiley Online Library
Aim: To investigate the role of chondrocyte apoptosis in the initiation and severity of articular
cartilage (AC) damage. Methods: Articular cartilage from equine metacarpophalangeal …

Apoptosis in osteoarthritis: morphology, mechanisms, and potential means for therapeutic intervention.

EO Johnson, A Charchandi, GC Babis… - Journal of surgical …, 2008 - europepmc.org
Osteoarthritis (OA) is the most common chronic joint disorder found in the aging population
and is primarily characterized by loss of articular cartilage. Because chondrocytes are …

Osteoarthritis chondrocytes die by apoptosis: a possible pathway for osteoarthritis pathology

FJ Blanco, R Guitian, E Vázquez‐Martul… - … : Official Journal of …, 1998 - Wiley Online Library
Objective To determine which kind of cell death occurs in cartilage from patients with
osteoarthritis (OA). Methods Seven normal and 16 OA cartilage samples were collected at …

Increased apoptosis in human osteoarthritic cartilage corresponds to reduced cell density and expression of caspase‐3

M Sharif, A Whitehouse, P Sharman… - … : Official Journal of …, 2004 - Wiley Online Library
Objective Chondrocyte apoptosis has been described in both human and experimentally
induced osteoarthritis (OA), but its importance in the etiopathogenesis of OA is uncertain …

Chondrocyte death involvement in osteoarthritis

S Salucci, E Falcieri, M Battistelli - Cell and tissue research, 2022 - Springer
Chondrocyte apoptosis is known to contribute to articular cartilage damage in osteoarthritis
and is correlated to a number of cartilage disorders. Micromass cultures represent a …

Chondrocyte apoptosis in the pathogenesis of osteoarthritis

HS Hwang, HA Kim - International journal of molecular sciences, 2015 - mdpi.com
Apoptosis is a highly-regulated, active process of cell death involved in development,
homeostasis and aging. Dysregulation of apoptosis leads to pathological states, such as …

Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis

S Hashimoto, RL Ochs, S Komiya… - Arthritis & Rheumatism …, 1998 - Wiley Online Library
Objective To examine the occurrence of apoptosis in human osteoarthritis (OA) cartilage,
and to determine its relationship to cartilage degradation. Methods Knee cartilage was …

Increased chondrocyte apoptosis is associated with progression of osteoarthritis in spontaneous Guinea pig models of the disease

Z Zamli, MA Adams, JF Tarlton, M Sharif - International journal of …, 2013 - mdpi.com
Osteoarthritis (OA) is the most common joint disease characterised by degradation of
articular cartilage and bone remodelling. For almost a decade chondrocyte apoptosis has …

Apoptotic cell death is not a widespread phenomenon in normal aging and osteoarthritic human articular knee cartilage: a study of proliferation, programmed cell …

T Aigner, M Hemmel, D Neureiter… - … : official Journal of …, 2001 - Wiley Online Library
Objective Chondrocytes are crucial for adequate matrix balance and function. Cell
proliferation and, recently, extensive apoptotic cell death have been reported in …