The aim of the present study is to synthesize and evaluate new potential chemotherapeutic
anti-tumor agents. Several thiazolo-, pyrido-, pyrano-and lactam steroid derivatives were …

Hetero-steroids, hybrid anticancer agents, have received much interest in view of their
numerous and promising biological activities. In this study, a novel class of hetero-steroids …

Colorectal cancer (CRC) is one of the malignant tumors with high incidence, and is mainly
treated by chemotherapy at present. However, during CRC treatment, long-term use of …

Oxysterols are 27-carbon oxidation products of cholesterol metabolism. Oxysterols possess
several biological actions, including the promotion of cell death. Here, we examined the …

1H nuclear magnetic resonance (NMR)-based metabolomics can rapidly detect metabolic
shift under various stimulus; thus, it facilitated the dissection of the therapeutic mechanisms …

Phytosterols have been proposed to act as potent anticancer agents. However the
mechanism of their action has not been elucidated yet. Thus, the aim of our study was to …

Triterpenoids are implicated in the chemoprevention of various cancers. Current challenge
is to define the molecular mechanism underlying the chemopreventive activity of …

Oxysterols are oxidation products of cholesterol. Cholestane-3β, 5α, 6β-triol (abbreviated as
triol) is one of the most abundant and active oxysterols. Here, we report that triol exhibits anti …

Some novel B-norcholesterols with different substituted groups were synthesized. The
antiproliferative activity of the compounds against cervical carcinoma (HeLa), liver cancer …

Steroids form a group of secondary metabolites having diversity in their structure and
biological functions. These natural products, although often linked with the deleterious effect …