1H nuclear magnetic resonance (NMR)-based metabolomics can rapidly detect metabolic
shift under various stimulus; thus, it facilitated the dissection of the therapeutic mechanisms …

Background Triple-negative breast cancer (TNBC) is a kind of malignant tumor with higher
recurrence and metastasis rate. According to historical records, the dry rhizomes Cyperus …

Oxysterols are oxidation products of cholesterol. Cholestane-3β, 5α, 6β-triol (abbreviated as
triol) is one of the most abundant and active oxysterols. Here, we report that triol exhibits anti …

Phytosterols have been proposed to act as potent anticancer agents. However the
mechanism of their action has not been elucidated yet. Thus, the aim of our study was to …

In this work, we studied indolium and benzothiazolium pentamethine salts 1–3 as novel type
of receptors for the recognition of sulphated signalling molecules (sulphated steroids …

The synthesis and cytotoxic studies of a new series of 16E-arylidene androstene derivatives
are reported herein. The impact of incorporating bis-tertiary amino functionalities in the …

Steroids form a group of secondary metabolites having diversity in their structure and
biological functions. These natural products, although often linked with the deleterious effect …

Resveratrol and its analogs are considered to be a promising drug candidate for treatment of
cancer and different age‐associated diseases. In the present study we have investigated the …

There are many kinds of estrogens, and endogenous estrogens produce a variety of
estrogen metabolites with similar structure but with different physiological effects after …

In this study, we have investigated the genotoxic, cytostatic, antineoplastic and apoptotic
effects of three newly synthesized modified steroidal esters, having as alkylating agent pN, N …