Androstene steroids are metabolites of dehydroepiandrosterone and exist as androstene‐
diols or‐triols in α‐and β‐epimeric forms based upon the placement of the hydroxyl groups …

Background Polygonum multiflorum (PM) is a core herb that enhances immunity. It can also
detoxify, reduce swelling, and intercept malaria. Its main components, emodin (EMD) and 2 …

Introduction Zearalenone (ZEN) is one of the most widely distributed toxins that
contaminates many crops and foods. Its major metabolites are α-Zearalenol (α-zol) and β …

Sterols can be metabolized by gut microbiota. The cholesterol metabolites have been
proposed as promoters of colorectal cancer (CRC), while the effect of plant sterol …

Background Emerging hallmark of cancer is reprogrammed cellular metabolism, increased
glycolytic metabolism is physiological characteristic of human malignant neoplasms …

Polygonum multiflorum (PM) is a perennial herbal medicine that inhibits osteopenia of
osteoporosis caused by estrogen deficiency and shows estrogen-like activity. Components …

As an anticancer agent, irinotecan (CPT-11) has been widely applied in clinical, especially
in the treatment of colorectal cancer. However, its clinical use has long been limited by the …

Objective To study antitumor effect of β-sitosterol and its mechanism in H 22 tumor-bearing
mice. Methods The tumor-bearing ICR mouse model was established with intraperitoneal …

In this study we report the cytotoxic effect on human cancer cells of two series of novel
progesterone derivatives; the first containing an aromatic ester (8a–e) or a carbamate …

The present study deals with in silico prediction and in vitro evaluation of the selective
cytotoxic effects of triterpenoids on tumorigenic human c-Ha-ras and mouse c-myc …