From cholesterol to oxysterols. Current data

B Luu - Comptes Rendus des Seances de la Societe de …, 1995 - europepmc.org
Oxysterols, a class of cholesterol oxidation products exhibit several important biological
activities. Some of these natural compounds are potent inhibitors of the enzyme HMG-CoA …

Metabolomic analysis uncovered an association of serum phospholipid levels with estrogen-induced mammary tumors in female ACI/Seg rats

Y Okamoto, A Aoki, K Ueda, H Jinno - Toxicology letters, 2018 - Elsevier
Estrogen is reported to be involved in mammary tumorigenesis. To unveil metabolic
signatures for estrogen-induced mammary tumorigenesis, we carried out serum …

[HTML][HTML] Therapeutic strategies and potential actions of female sex steroid hormones and their receptors in Colon cancer based on preclinical studies

AA Mahbub - Life, 2022 - mdpi.com
Several epidemiological studies have reported that the use of female sex steroid hormones
could reduce the risk of colon cancer (CRC). This review summarizes the available data …

Therapeutic potential of steroidal alkaloids in cancer and other diseases

QW Jiang, MW Chen, KJ Cheng, PZ Yu… - Medicinal research …, 2016 - Wiley Online Library
Steroidal alkaloids are a class of secondary metabolites isolated from plants, amphibians,
and marine invertebrates. Evidence accumulated in the recent two decades demonstrates …

[HTML][HTML] Synthesis and evaluation of new sterol derivatives as potential antitumor agents

X Chen, YJ Gan, Y Yu, Y Zhang - RSC advances, 2018 - pubs.rsc.org
The current optimization of tetrazanbigen (TNBG) on the C-ring provided a series of new
sterol derivatives 2a–2n. All new synthesized compounds were screened for their anti …

[HTML][HTML] Promoting liver cancer cell apoptosis effect of Tribulus terrestris L. via reducing sphingosine level was confirmed by network pharmacology with metabolomics

J Zhao, JQ Zhang, TT Li, S Qiao, SL Jiang - Heliyon, 2023 - cell.com
Abstract Background Tribulus terrestris L.(TT) is one of the most common Chinese herbs and
distributes in various regions in China. TT was first documented to treat breast cancer in …

[HTML][HTML] Cell metabolomics study on the anticancer effects of Ophiopogon japonicus against lung cancer cells using UHPLC/Q-TOF-MS analysis

Q Liu, JM Shen, HJ Hong, Q Yang, W Liu… - Frontiers in …, 2022 - frontiersin.org
Ophiopogon japonicus (OJ) is a traditional Chinese herbal medicine that has been used for
thousands of years. Recently, the anticancer effects of OJ have been reported in multiple …

Uhplc–ms-based metabolomics analysis on mice bearing neoplasm (h22) for hispidulin

F Li, X Li, Y Miao, C Shan, F Yuan, C Ma… - … of pharmaceutical and …, 2016 - Elsevier
Although some physiological and pathological function parameters of hepatitis and liver
cancer have been investigated in relation to hispidulin (5, 7, 4′-trihydroxy-6 …

Immune up-regulation and tumor apoptosis by androstene steroids

RM Loria - Steroids, 2002 - Elsevier
β Androstenes steroid up-regulates immunity to increase resistance against lethal infection
and lethal radiation, and mediates a rapid recovery of hematopoietic precursor cells after …

Chemopreventive effect of saponin isolated from Gymnema sylevestre on prostate cancer through in silico and in vivo analysis

R Pon Nivedha, V Suryanarayanan, C Selvaraj… - Medicinal Chemistry …, 2017 - Springer
Prostate cancer is one of the frequently diagnosed cancers in men. In prostate cancer,
initiation to the appearance of symptoms is a very long period. Due to its high latency period …