[HTML][HTML] Caffeine ameliorates hyperoxia-induced lung injury by protecting GCH1 function in neonatal rat pups

X Jing, YW Huang, J Jarzembowski, Y Shi… - Pediatric …, 2017 - nature.com
Background Bronchopulmonary dysplasia (BPD) is a major morbidity in premature infants,
and impaired angiogenesis is considered a major contributor to BPD. Early caffeine …

[HTML][HTML] Caffeine is associated with improved alveolarization and angiogenesis in male mice following hyperoxia induced lung injury

V Dumpa, L Nielsen, H Wang, VHS Kumar - BMC pulmonary medicine, 2019 - Springer
Background Caffeine therapy for apnea of prematurity reduces the incidence of
bronchopulmonary dysplasia (BPD) in premature neonates. Several mechanisms, including …

[HTML][HTML] Antioxidative effects of caffeine in a hyperoxia-based rat model of bronchopulmonary dysplasia

S Endesfelder, E Strauß, T Scheuer, T Schmitz… - Respiratory …, 2019 - Springer
Background While additional oxygen supply is often required for the survival of very
premature infants in intensive care, this also brings an increasing risk of progressive lung …

Attenuation of endoplasmic reticulum stress by caffeine ameliorates hyperoxia-induced lung injury

RJ Teng, X Jing, T Michalkiewicz… - … of Physiology-Lung …, 2017 - journals.physiology.org
Rodent pups exposed to hyperoxia develop lung changes similar to bronchopulmonary
dysplasia (BPD) in extremely premature infants. Oxidative stress from hyperoxia can injure …

Caffeine prevents hyperoxia-induced functional and structural lung damage in preterm rabbits

T Nagatomo, J Jiménez, J Richter, S De Baere… - Neonatology, 2016 - karger.com
Background: Caffeine is a commonly used drug for apnea of prematurity. It may, however,
also have a beneficial effect on bronchopulmonary dysplasia (BPD), which is the most …

[HTML][HTML] Caffeine prevents hyperoxia-induced lung injury in neonatal mice through NLRP3 inflammasome and NF-κB pathway

S Chen, Q Wu, D Zhong, C Li, L Du - Respiratory Research, 2020 - Springer
Background Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in
premature infants and hyperoxia exposure is a major cause. In hyperoxic lung injury animal …

Differential concentration-specific effects of caffeine on cell viability, oxidative stress, and cell cycle in pulmonary oxygen toxicity in vitro

KK Tiwari, C Chu, X Couroucli, B Moorthy… - Biochemical and …, 2014 - Elsevier
Caffeine is used to prevent bronchopulmonary dysplasia (BPD) in premature neonates.
Hyperoxia contributes to the development of BPD, inhibits cell proliferation and decreases …

[HTML][HTML] Caffeine administration modulates TGF-β signaling but does not attenuate blunted alveolarization in a hyperoxia-based mouse model of bronchopulmonary …

P Rath, C Nardiello, DE Surate Solaligue, R Agius… - Pediatric …, 2017 - nature.com
Background: Caffeine is widely used to manage apnea of prematurity, and reduces the
incidence of bronchopulmonary dysplasia (BPD). Deregulated transforming growth factor …

Prevention of oxygen‐induced inflammatory lung injury by caffeine in neonatal rats

S Endesfelder, E Strauß, I Bendix… - Oxidative medicine …, 2020 - Wiley Online Library
Background. Preterm birth implies an array of respiratory diseases including apnea of
prematurity and bronchopulmonary dysplasia (BPD). Caffeine has been introduced to treat …

Caffeine and bronchopulmonary dysplasia: Clinical benefits and the mechanisms involved

Y Yuan, Y Yang, X Lei, W Dong - Pediatric Pulmonology, 2022 - Wiley Online Library
Bronchopulmonary dysplasia (BPD) is a chronic respiratory disease that occurs during the
neonatal period and is commonly associated with prematurity. This condition results in a …