Stroke genetics and how it Informs novel drug discovery

J Valančienė, K Melaika, A Šliachtenko… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Stroke is one of the main causes of death and disability worldwide.
Nevertheless, despite the global burden of this disease, our understanding is limited and …

Ischemic stroke genetics: what is new and how to apply it in clinical practice?

A Ekkert, A Šliachtenko, J Grigaitė, B Burnytė, A Utkus… - Genes, 2021 - mdpi.com
The etiology of ischemic stroke is multifactorial. Although receiving less emphasis, genetic
causes make a significant contribution to ischemic stroke genesis, especially in early-onset …

Stroke genetics update: 2011

JW Cole, JF Meschia - Current cardiovascular risk reports, 2011 - Springer
Although stroke remains a leading cause of disability and mortality worldwide, recently there
have been significant advances related to our understanding of the genetic basis of stroke …

Stroke genetics: discovery, biology, and clinical applications

M Dichgans, SL Pulit, J Rosand - The Lancet Neurology, 2019 - thelancet.com
Stroke, a leading cause of long-term disability and death worldwide, has a heritable
component. Recent gene discovery efforts have expanded the number of known single …

Stroke genetics: prospects for personalized medicine

HS Markus - BMC medicine, 2012 - Springer
Epidemiologic evidence supports a genetic predisposition to stroke. Recent advances,
primarily using the genome-wide association study approach, are transforming what we …

[HTML][HTML] Genetics in Ischemic Stroke: Current Perspectives and Future Directions

K Zhang, SSE Loong, LZH Yuen… - Journal of …, 2023 - mdpi.com
Ischemic stroke is a heterogeneous condition influenced by a combination of genetic and
environmental factors. Recent advancements have explored genetics in relation to various …

Grand challenges in stroke genomics

M Fornage - Frontiers in Stroke, 2022 - frontiersin.org
Stroke, a leading cause of death, disability and dementia, is a significant public health
burden with enormous financial and human costs that are projected to rise over the next …

Stroke genetics: discovery, insight into mechanisms, and clinical perspectives

S Debette, HS Markus - Circulation Research, 2022 - Am Heart Assoc
Stroke is the second leading cause of death worldwide and a complex, heterogeneous
condition. In this review, we provide an overview of the current knowledge on monogenic …

Genetics of stroke

M Fornage - Current atherosclerosis reports, 2009 - Springer
Stroke is the third leading cause of death and the leading cause of severe long-term
disability in developed countries. Despite significant progress in understanding the risk …

Stroke and etiopathogenesis: what is known?

T Ciarambino, P Crispino, E Mastrolorenzo, A Viceconti… - Genes, 2022 - mdpi.com
Background: A substantial portion of stroke risk remains unexplained, and a contribution
from genetic factors is supported by recent findings. In most cases, genetic risk factors …