Metabolic engineering

G Stephanopoulos - Current Opinion in Biotechnology, 1994 - Elsevier
Metabolic engineering is not another form of classic manipulation of intermediary
metabolism; rather, it is the purposeful design of metabolic networks. The metabolic …

A perspective of metabolic engineering strategies: moving up the systems hierarchy

T Bulter, JR Bernstein, JC Liao - Biotechnology and …, 2003 - Wiley Online Library
Metabolic engineering has been established as an important field in biotechnology. It
involves the analysis, design, and alteration of the stoichiometric network using …

Design principles and operating principles: the yin and yang of optimal functioning

EO Voit - Mathematical biosciences, 2003 - Elsevier
Metabolic engineering has as a goal the improvement of yield of desired products from
microorganisms and cell lines. This goal has traditionally been approached with …

Metabolic engineering: techniques for analysis of targets for genetic manipulations

J Nielsen - Biotechnology and bioengineering, 1998 - Wiley Online Library
Metabolic engineering has been defined as the purposeful modification of intermediary
metabolism using recombinant DNA techniques. With this definition metabolic engineering …

The essence of metabolic engineering

GN Stephanopoulos, AA Aristidou, J Nielsen - … Engineering: Principles and …, 1998 - Elsevier
Metabolic engineering is a new field with applications in the production of chemicals, fuels,
materials, pharmaceuticals, and medicine at the genetic level. The field's novelty is in the …

[HTML][HTML] Metabolic pathway engineering

HS Alper, JL Avalos - Synthetic and systems biotechnology, 2018 - ncbi.nlm.nih.gov
Organisms can be engineered to produce a wide variety of compounds by either enhancing
endogenous metabolic pathways, or by introducing exogenous pathways that are either …

Metabolic engineering—Integrating methodologies of molecular breeding and bioprocess systems engineering

H Shimizu - Journal of bioscience and bioengineering, 2002 - Elsevier
Metabolic engineering is an integrating methodology of analysis and synthesis for the
improvement of flux distribution of metabolic pathways in complicated bioprocesses, which …

Metabolic engineering: principles and methodologies

G Stephanopoulos, AA Aristidou, J Nielsen - 1998 - books.google.com
Metabolic engineering is a new field with applications in the production of chemicals, fuels,
materials, pharmaceuticals, and medicine at the genetic level. The field's novelty is in the …

[图书][B] Pathway analysis and optimization in metabolic engineering

NV Torres, EO Voit - 2002 - books.google.com
Facility in the targeted manipulation of the genetic and metabolic composition of organisms,
combined with unprecedented computational power, is forging a niche for a new …

Metabolic design: how to engineer a living cell to desired metabolite concentrations and fluxes

BN Kholodenko, M Cascante, JB Hoek… - Biotechnology and …, 1998 - Wiley Online Library
A biotechnological aim of genetic engineering is to increase the intracellular concentration
or secretion of valuable compounds, while making the other concentrations and fluxes …