[HTML][HTML] Plasma phosphorylated-tau181 as a predictive biomarker for Alzheimer's amyloid, tau and FDG PET status

XN Shen, YY Huang, SD Chen, Y Guo, L Tan… - Translational …, 2021 - nature.com
Abstract Plasma phosphorylated-tau181 (p-tau181) showed the potential for Alzheimer's
diagnosis and prognosis, but its role in detecting cerebral pathologies is unclear. We aimed …

Plasma phospho-tau181 increases with Alzheimer's disease clinical severity and is associated with tau-and amyloid-positron emission tomography

MM Mielke, CE Hagen, J Xu, X Chai, P Vemuri… - Alzheimer's & …, 2018 - Elsevier
Introduction We examined and compared plasma phospho-tau181 (pTau181) and total
tau:(1) across the Alzheimer's disease (AD) clinical spectrum;(2) in relation to brain amyloid …

Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer's Disease Neuroimaging Initiative

TK Karikari, AL Benedet, NJ Ashton… - Molecular …, 2021 - nature.com
Whilst cerebrospinal fluid (CSF) and positron emission tomography (PET) biomarkers for
amyloid-β (Aβ) and tau pathologies are accurate for the diagnosis of Alzheimer's disease …

[HTML][HTML] Longitudinal plasma phosphorylated tau 181 tracks disease progression in Alzheimer's disease

SD Chen, YY Huang, XN Shen, Y Guo, L Tan… - Translational …, 2021 - nature.com
To assess plasma phosphorylated tau181 (p-tau181) as a progression biomarker in
Alzheimer's disease (AD), we examined longitudinal plasma p-tau181 of 1184 participants …

[HTML][HTML] Quantification of plasma phosphorylated tau to use as a biomarker for brain Alzheimer pathology: pilot case-control studies including patients with Alzheimer's …

H Tatebe, T Kasai, T Ohmichi, Y Kishi, T Kakeya… - Molecular …, 2017 - Springer
Background There is still a substantial unmet need for less invasive and lower-cost blood-
based biomarkers to detect brain Alzheimer's disease (AD) pathology. This study is aimed to …

Plasma P-tau181 in Alzheimer's disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer's dementia

S Janelidze, N Mattsson, S Palmqvist, R Smith… - Nature medicine, 2020 - nature.com
Plasma phosphorylated tau181 (P-tau181) might be increased in Alzheimer's disease (AD),
but its usefulness for differential diagnosis and prognosis is unclear. We studied plasma P …

Blood phosphorylated tau 181 as a biomarker for amyloid burden on brain PET in cognitively healthy adults

ER McGrath, AS Beiser, A O'Donnell… - Journal of …, 2022 - content.iospress.com
Background: Plasma phosphorylated-tau181 (p-tau181) is a promising biomarker for
Alzheimer's disease (AD) and may offer utility for predicting preclinical disease. Objective …

[HTML][HTML] Plasma p-tau181 level predicts neurodegeneration and progression to Alzheimer's dementia: a longitudinal study

YL Wang, J Chen, ZL Du, H Weng, Y Zhang… - Frontiers in …, 2021 - frontiersin.org
Background: Plasma-based biomarkers would be potential biomarkers for early diagnosis of
Alzheimer's disease (AD) because they are more available and cost-effective than …

[HTML][HTML] Head-to-head comparison between plasma p-tau217 and flortaucipir-PET in amyloid-positive patients with cognitive impairment

NS Mundada, JC Rojas, L Vandevrede… - Alzheimer's Research & …, 2023 - Springer
Background Plasma phosphorylated tau (p-tau) has emerged as a promising biomarker for
Alzheimer's disease (AD). Studies have reported strong associations between p-tau and tau …

Phospho‐specific plasma p‐tau181 assay detects clinical as well as asymptomatic Alzheimer's disease

S De Meyer, J Vanbrabant… - Annals of clinical …, 2022 - Wiley Online Library
Abstract Objective Plasma phosphorylated‐tau‐181 (p‐tau181) reliably detects clinical
Alzheimer's disease (AD) as well as asymptomatic amyloid‐β (Aβ) pathology, but is …