A novel CCR4 antagonist induces potent anti-tumor response through inhibition of Treg migration into the tumor microenvironment
R Nair, C Abbineni, KC Talluri, AA Dhudashiya, A AB… - Cancer Research, 2024 - AACR
Regulatory T cells (Tregs), an immunosuppressive subset of CD4+ T cells, play a vital role in
maintaining immune homeostasis by regulating response to self antigens and maintaining …
maintaining immune homeostasis by regulating response to self antigens and maintaining …
Novel piperidinyl-azetidines as potent and selective CCR4 antagonists elicit antitumor response as a single agent and in combination with checkpoint inhibitors
O Robles, JJ Jackson, L Marshall, O Talay… - Journal of Medicinal …, 2020 - ACS Publications
The C–C chemokine receptor 4 (CCR4) is broadly expressed on regulatory T cells (Treg) as
well as other circulating and tissue-resident T cells. Treg can be recruited to the tumor …
well as other circulating and tissue-resident T cells. Treg can be recruited to the tumor …
[PDF][PDF] Potent and selective CC chemokine receptor (CCR4) antagonists potentiate anti-tumor immune responses by inhibiting regulatory T cells (Treg)
O Talay, L Marshall, C Meleza, MK Reilly, O Robles… - J Immunother …, 2017 - rapt.com
Conclusions Naturally suppressive CD4+ Foxp3+ Treg are essential for immune tolerance.
Although Treg-mediated suppression of effector cells is important to control inflammation …
Although Treg-mediated suppression of effector cells is important to control inflammation …
Development of a CCR8 monoclonal antibody which blocks CCR8 signaling and abolishes the immunosuppressive function of Treg for the treatment of cancer
G Fan, J Wang, N Wang, Y Zhang, Y Zhang, B Tian… - Cancer Research, 2023 - AACR
Within the tumor microenvironment (TME), regulatory T (Treg) cells are one attractive cell
type for targeting as they play a critical role in immunosuppression. Therapeutic strategies …
type for targeting as they play a critical role in immunosuppression. Therapeutic strategies …
CCR4 Antagonists Inhibit Treg Trafficking into the Tumor Microenvironment
JM Ketcham, LA Marshall, O Talay - ACS Medicinal Chemistry …, 2018 - ACS Publications
Recruitment of naturally occurring suppressive CD4+, CD25+, and FOXP3+ regulatory T
cells (Treg) to the tumor microenvironment (TME) has the potential to weaken the antitumor …
cells (Treg) to the tumor microenvironment (TME) has the potential to weaken the antitumor …
Development of a CCR8 monoclonal antibody to block CCR8 signaling and to abolish the immunosuppressive function of Treg for the treatment of cancers.
G Fan, JF Wang, Z Wang, Y Zhang, Y Zhang, B Tian - 2023 - ascopubs.org
e14506 Background: The tumor microenvironment (TME) contains regulatory T (Treg) cells,
which play a critical role in immunosuppression and are thus an attractive target for cancer …
which play a critical role in immunosuppression and are thus an attractive target for cancer …
Discovery of a Potent and Selective CCR4 Antagonist That Inhibits Treg Trafficking into the Tumor Microenvironment
JJ Jackson, JM Ketcham, A Younai… - Journal of Medicinal …, 2019 - ACS Publications
Recruitment of suppressive CD4+ FOXP3+ regulatory T cells (Treg) to the tumor
microenvironment (TME) has the potential to weaken the antitumor response in patients …
microenvironment (TME) has the potential to weaken the antitumor response in patients …
CCR8 antagonist suppresses liver cancer progression via turning tumor-infiltrating Tregs into less immunosuppressive phenotype
JF Wang, B Tian, Z Wang, M Cao, N Wang, X Jia… - 2024 - researchsquare.com
Regulatory T cells (Tregs) are main immunosuppressive cells in tumor immune
microenvironment (TIME). However, systemic Treg depletion is not favored due to the crucial …
microenvironment (TIME). However, systemic Treg depletion is not favored due to the crucial …
[HTML][HTML] Targeting the CCL2/CCR2 axis in cancer immunotherapy: one stone, three birds?
L Fei, X Ren, H Yu, Y Zhan - Frontiers in Immunology, 2021 - frontiersin.org
CCR2 is predominantly expressed by monocytes/macrophages with strong proinflammatory
functions, prompting the development of CCR2 antagonists to dampen unwanted immune …
functions, prompting the development of CCR2 antagonists to dampen unwanted immune …
Differential expression of CCR8 in tumors versus normal tissue allows specific depletion of tumor-infiltrating T regulatory cells by GS-1811, a novel Fc-optimized anti …
JD Weaver, EC Stack, JA Buggé, C Hu… - …, 2022 - Taylor & Francis
The presence of T regulatory (Treg) cells in the tumor microenvironment is associated with
poor prognosis and resistance to therapies aimed at reactivating anti-tumor immune …
poor prognosis and resistance to therapies aimed at reactivating anti-tumor immune …