Tumors evade immune destruction by actively inducing immune tolerance through the
recruitment of CD4+ CD25+ Foxp3+ regulatory T cells (Treg). We have previously described …

Two aspects of cancer progression that contribute to malignancy are the ability of the tumor
to metastasize to remote locations in the body, and the ability to evade effective host anti …

The human CC chemokine receptor 8 (CCR8) is a promising drug target for cancer
immunotherapy and autoimmune disease. Besides human and viral chemokines, previous …

Tumor-infiltrating Tregs (TITR) constitute a sub-family of immuno-suppressive cells
abundantly found in multiple solid cancers. They play a critical role in tumor progression and …

CAR T cell therapy remains ineffective in solid tumors, due largely to poor infiltration and T
cell suppression at the tumor site. T regulatory (Treg) cells suppress the immune response …

Abstract Background: Regulatory T cells (Tregs) are one of the representative
immunosuppressive cells playing a critical role in tumor microenvironment by suppressing …

Background/Aim: The effectiveness of adoptive T cell therapy for solid tumors remains
suboptimal, partly attributed to insufficient T cell infiltration into the tumor site. A promising …

An important hallmark of the human immune system is to provide adaptive immunity against
pathogens but tolerance toward self-antigens. The CC-chemokine receptor 7 (CCR7) …

The human CC chemokine receptor 8 (CCR8) is specifically expressed on tumor-infiltrating
regulatory T cells (TITRs) and is a promising drug target for cancer immunotherapy …

Infiltration of regulatory T (Treg) cells, an immunosuppressive population of CD4+ T cells,
into solid cancers represents a barrier to cancer immunotherapy. Chemokine receptors are …