Hepatic steatosis in n-3 fatty acid depleted mice: focus on metabolic alterations related to tissue fatty acid composition

BD Pachikian, AM Neyrinck, PD Cani, L Portois… - BMC physiology, 2008 - Springer
Background There are only few data relating the metabolic consequences of feeding diets
very low in n-3 fatty acids. This experiment carried out in mice aims at studying the impact of …

Hepatic n-3 polyunsaturated fatty acid depletion promotes steatosis and insulin resistance in mice: genomic analysis of cellular targets

BD Pachikian, A Essaghir, JB Demoulin, AM Neyrinck… - PloS one, 2011 - journals.plos.org
Patients with non-alcoholic fatty liver disease are characterised by a decreased n-3/n-6
polyunsaturated fatty acid (PUFA) ratio in hepatic phospholipids. The metabolic …

Dietary omega-3 polyunsaturated fatty acids alter the fatty acid composition of hepatic and plasma bioactive lipids in C57BL/6 mice: a lipidomic approach

KA Balogun, CJ Albert, DA Ford, RJ Brown… - PloS one, 2013 - journals.plos.org
Background Omega (n)-3 polyunsaturated fatty acids (PUFA) are converted to bioactive lipid
components that are important mediators in metabolic and physiological pathways; …

Endogenous synthesis of n-3 polyunsaturated fatty acids in Fat-1 mice is associated with increased mammary gland and liver syndecan-1

H Sun, Y Hu, Z Gu, MD Wilson, YQ Chen, LL Rudel… - PLoS …, 2011 - journals.plos.org
Long chain n-3 PUFA have been shown to have chemopreventive properties against breast
cancer through various mechanisms. One pathway, studied in human breast cancer cell …

Eicosapentaenoic and docosahexaenoic acid-enriched high fat diet delays the development of fatty liver in mice

NK Soni, I Nookaew, AS Sandberg… - Lipids in health and …, 2015 - Springer
Background Low hepatic content of n-3 PUFA has been associated with NAFLD in humans.
Whether this is associated with reduced dietary intake or increased turnover of these FA is …

Is there an optimal dose for dietary linoleic acid? Lessons from essential fatty acid deficiency supplementation and adipocyte functions in rats

I Harant-Farrugia, J Garcia, MC Iglesias-Osma… - Journal of physiology …, 2014 - Springer
Differential effects of n-3 and n-6 polyunsaturated fatty acids (PUFAs) have been
demonstrated on adipose tissue physiology. Facing to the widely recognized beneficial …

n-3 PUFA added to high-fat diets affect differently adiposity and inflammation when carried by phospholipids or triacylglycerols in mice

M Awada, A Meynier, CO Soulage, L Hadji… - Nutrition & …, 2013 - Springer
Background Dietary intake of n-3 polyunsaturated fatty acids (PUFA) is primarily recognized
to protect against cardiovascular diseases, cognitive dysfunctions and the onset of obesity …

Effects of dietary polyunsaturated n-3 fatty acids on dyslipidemia and insulin resistance in rodents and humans. A review

YB Lombardo, AG Chicco - The Journal of nutritional biochemistry, 2006 - Elsevier
For many years, clinical and animal studies on polyunsaturated n-3 fatty acids (PUFAs),
especially those from marine oil, eicosapentaenoic acid (20: 5, n-3) and docosahexaenoic …

Comparison of the effects of monounsaturated fatty acids and polyunsaturated fatty acids on liver lipid disorders in obese mice

W Liu, M Zhu, M Gong, W Zheng, X Zeng, Q Zheng, X Li… - Nutrients, 2023 - mdpi.com
Obesity is a recognized epidemic worldwide, and the accumulation of excess free saturated
fatty acids (SFAs) in cells induces cellular lipotoxic damage and increases the risk of a wide …

[HTML][HTML] Metabolic responses to high-fat diets rich in n-3 or n-6 long-chain polyunsaturated fatty acids in mice selected for either high body weight or leanness explain …

K Nuernberg, BH Breier, SN Jayasinghe… - Nutrition & …, 2011 - Springer
Increasing evidence suggests that diets high in polyunsaturated fatty acids (PUFA) confer
health benefits by improving insulin sensitivity and lipid metabolism in liver, muscle and …