In utero combined di-(2-ethylhexyl) phthalate and diethyl phthalate exposure cumulatively impairs rat fetal Leydig cell development

G Hu, J Li, Y Shan, X Li, Q Zhu, H Li, Y Wang, X Chen… - Toxicology, 2018 - Elsevier
Abstract Phthalate diesters, including di-(2-ethylhexyl) phthalate (DEHP) and diethyl
phthalate (DEP), are chemicals to which humans are ubiquitously exposed. Humans are …

Cumulative effects of dibutyl phthalate and diethylhexyl phthalate on male rat reproductive tract development: altered fetal steroid hormones and genes

KL Howdeshell, J Furr, CR Lambright… - Toxicological …, 2007 - academic.oup.com
Exposure to plasticizers di (n-butyl) phthalate (DBP) and diethylhexyl phthalate (DEHP)
during sexual differentiation causes male reproductive tract malformations in rats and …

Di (2-ethylhexyl) phthalate exposure during prenatal development causes adverse transgenerational effects on female fertility in mice

S Rattan, E Brehm, L Gao, JA Flaws - Toxicological Sciences, 2018 - academic.oup.com
Abstract Di (2-ethylhexyl) phthalate (DEHP) is a ubiquitous environmental toxicant and
endocrine disrupting chemical, but little is known about its effects on female reproduction …

Dipentyl phthalate dosing during sexual differentiation disrupts fetal testis function and postnatal development of the male Sprague-Dawley rat with greater relative …

BR Hannas, J Furr, CS Lambright… - Toxicological …, 2011 - academic.oup.com
Phthalate esters (PEs) constitute a large class of plasticizer compounds that are widely used
for many consumer product applications. Ten or more members of the PE class of …

Dose-Response Assessment of Fetal Testosterone Production and Gene Expression Levels in Rat Testes Following InUtero Exposure to Diethylhexyl Phthalate …

BR Hannas, CS Lambright, J Furr… - Toxicological …, 2011 - academic.oup.com
Several phthalate esters have been linked to the Phthalate Syndrome, affecting male
reproductive development when administered to pregnant rats during in utero sexual …

A mixture of five phthalate esters inhibits fetal testicular testosterone production in the sprague-dawley rat in a cumulative, dose-additive manner

KL Howdeshell, VS Wilson, J Furr… - Toxicological …, 2008 - academic.oup.com
Phthalate diesters are chemicals to which humans are ubiquitously exposed. Exposure to
certain phthalates during sexual differentiation causes reproductive tract malformations in …

Prenatal exposure to an environmentally relevant phthalate mixture disrupts reproduction in F1 female mice

C Zhou, L Gao, JA Flaws - Toxicology and applied pharmacology, 2017 - Elsevier
Phthalates are used in a large variety of products, such as building materials, medical
devices, and personal care products. Most previous studies on the toxicity of phthalates …

In utero exposure to dipentyl phthalate disrupts fetal and adult Leydig cell development

H Chen, X Xin, M Liu, F Ma, Y Yu, J Huang… - Toxicology and Applied …, 2021 - Elsevier
Phthalates as plasticizers are widely used in many consumer products. Dipentyl phthalate
(DPeP) is one of phthalates. However, there are currently few data on whether DPeP …

Transgenerational effects of Di (2-ethylhexyl) phthalate in the male CRL: CD (SD) rat: added value of assessing multiple offspring per litter

LE Gray Jr, NJ Barlow, KL Howdeshell… - Toxicological …, 2009 - academic.oup.com
In the rat, some phthalates alter sexual differentiation at relatively low dosage levels by
altering fetal Leydig cell development and hormone synthesis, thereby inducing …

[HTML][HTML] The impact of Di-(2-ethylhexyl) Phthalate and Mono (2-ethylhexyl) Phthalate in placental development, function, and pathophysiology

LD Martínez-Razo, A Martínez-Ibarra… - Environment …, 2021 - Elsevier
Abstract Di (2-ethylhexyl) phthalate (DEHP) is a chemical widely distributed in the
environment as is extensively used in the plastic industry. DEHP is considered an endocrine …